MSRB3 protein (human) - STRING database

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MSRB3

Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes (192 aa)

Predicted Functional Partners:

MSRA

0.991

TXN

0.946

LEMD3

0.717

FAM19A3

0.626

DFNA5

0.581

MAST3

0.580

HMGA2

0.544

WDFY2

0.540

CCDC94

0.536

AZIN1

0.530

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AZIN1	MSRB3	ENSP00000337180	ENSP00000347324	Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding. Inhibits antizyme- dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.530
CCDC94	FAM19A3	ENSP00000262962	ENSP00000358644	Coiled-coil domain containing 94	Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family	0.671
CCDC94	MAST3	ENSP00000262962	ENSP00000262811	Coiled-coil domain containing 94	Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family	0.603
CCDC94	MSRB3	ENSP00000262962	ENSP00000347324	Coiled-coil domain containing 94	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.536
CCDC94	WDFY2	ENSP00000262962	ENSP00000298125	Coiled-coil domain containing 94	WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By sim [...]	0.526
DFNA5	MSRB3	ENSP00000339587	ENSP00000347324	Gasdermin-E; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.581
FAM19A3	CCDC94	ENSP00000358644	ENSP00000262962	Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family	Coiled-coil domain containing 94	0.671
FAM19A3	MAST3	ENSP00000358644	ENSP00000262811	Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family	Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family	0.653
FAM19A3	MSRB3	ENSP00000358644	ENSP00000347324	Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.626
FAM19A3	WDFY2	ENSP00000358644	ENSP00000298125	Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family	WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By sim [...]	0.623
HMGA2	MSRB3	ENSP00000437621	ENSP00000347324	High mobility group protein HMGI-C; Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity); Belongs to the HMGA family	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.544
LEMD3	MSRB3	ENSP00000308369	ENSP00000347324	Inner nuclear membrane protein Man1; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest; LEM domain containing	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.717
MAST3	CCDC94	ENSP00000262811	ENSP00000262962	Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family	Coiled-coil domain containing 94	0.603
MAST3	FAM19A3	ENSP00000262811	ENSP00000358644	Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family	Protein FAM19A3; Plays a role in the regulation of microglia polarization; Belongs to the FAM19/TAFA family	0.653
MAST3	MSRB3	ENSP00000262811	ENSP00000347324	Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.580
MAST3	WDFY2	ENSP00000262811	ENSP00000298125	Microtubule associated serine/threonine kinase 3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family	WD repeat and FYVE domain-containing protein 2; Acts in an adapter protein-like fashion to mediate the interaction between the kinase PRKCZ and its substrate VAMP2 and increases the PRKCZ-dependent phosphorylation of VAMP2. Positively regulates adipocyte differentiation, by facilitating the phosphorylation and thus inactivation of the anti-adipogenetic transcription factor FOXO1 by the kinase AKT1. Plays a role in endosomal control of AKT2 signaling; required for insulin-stimulated AKT2 phosphorylation and glucose uptake and insulin-stimulated phosphorylation of AKT2 substrates (By sim [...]	0.547
MSRA	MSRB3	ENSP00000313921	ENSP00000347324	Mitochondrial peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	0.991
MSRA	TXN	ENSP00000313921	ENSP00000363641	Mitochondrial peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates A [...]	0.986
MSRB3	AZIN1	ENSP00000347324	ENSP00000337180	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	Antizyme inhibitor 1; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme- binding. Inhibits antizyme- dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production	0.530
MSRB3	CCDC94	ENSP00000347324	ENSP00000262962	Methionine-R-sulfoxide reductase B3; Catalyzes the reduction of free and protein-bound methionine sulfoxide to methionine. Isoform 2 is essential for hearing; Deafness associated genes	Coiled-coil domain containing 94	0.536

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