ATRNL1 protein (human) - STRING database

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ATRNL1

Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing (1379 aa)

Predicted Functional Partners:

MC4R

0.809

FAM160B1

0.657

TRUB1

0.653

MC1R

0.630

MGRN1

0.576

BEGAIN

0.519

NAGPA

0.453

CLEC3B

0.448

C20orf196

0.444

RNF157

0.439

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATRNL1	BEGAIN	ENSP00000347152	ENSP00000411124	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD)	0.519
ATRNL1	C20orf196	ENSP00000347152	ENSP00000305875	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Uncharacterized protein C20orf196; Chromosome 20 open reading frame 196	0.444
ATRNL1	CLEC3B	ENSP00000347152	ENSP00000296130	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Tetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis; C-type lectin domain containing	0.448
ATRNL1	FAM160B1	ENSP00000347152	ENSP00000358251	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Protein FAM160B1; Family with sequence similarity 160 member B1; Armadillo-like helical domain containing	0.657
ATRNL1	MC1R	ENSP00000347152	ENSP00000451605	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family	0.630
ATRNL1	MC4R	ENSP00000347152	ENSP00000299766	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Melanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP); Belongs to the G-protein coupled receptor 1 family	0.809
ATRNL1	MGRN1	ENSP00000347152	ENSP00000262370	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins	0.576
ATRNL1	NAGPA	ENSP00000347152	ENSP00000310998	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases	0.453
ATRNL1	RNF157	ENSP00000347152	ENSP00000269391	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	E3 ubiquitin ligase RNF157; E3 ubiquitin ligase that ubiquitinates APBB1 for its degradation by the proteasome and thus prevents apoptosis and promotes survival of neurons. Has a dual role in neurons as it is also required for dendrite growth and maintenance for which its ligase activity is not critical. May act as a scaffold molecule to regulate this process. Acts as a downstream effector of the interconnected PI3K and MAPK signaling pathways and thus participates in the regulation of the cell cycle; Ring finger proteins	0.439
ATRNL1	TRUB1	ENSP00000347152	ENSP00000298746	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs	0.653
BEGAIN	ATRNL1	ENSP00000411124	ENSP00000347152	Brain-enriched guanylate kinase-associated protein; May sustain the structure of the postsynaptic density (PSD)	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	0.519
C20orf196	ATRNL1	ENSP00000305875	ENSP00000347152	Uncharacterized protein C20orf196; Chromosome 20 open reading frame 196	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	0.444
C20orf196	NAGPA	ENSP00000305875	ENSP00000310998	Uncharacterized protein C20orf196; Chromosome 20 open reading frame 196	N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase; Catalyzes the second step in the formation of the mannose 6-phosphate targeting signal on lysosomal enzyme oligosaccharides by removing GlcNAc residues from GlcNAc-alpha-P- mannose moieties, which are formed in the first step. Also hydrolyzes UDP-GlcNAc, a sugar donor for Golgi N- acetylglucosaminyltransferases	0.422
CLEC3B	ATRNL1	ENSP00000296130	ENSP00000347152	Tetranectin; Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis; C-type lectin domain containing	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	0.448
FAM160B1	ATRNL1	ENSP00000358251	ENSP00000347152	Protein FAM160B1; Family with sequence similarity 160 member B1; Armadillo-like helical domain containing	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	0.657
FAM160B1	TRUB1	ENSP00000358251	ENSP00000298746	Protein FAM160B1; Family with sequence similarity 160 member B1; Armadillo-like helical domain containing	Probable tRNA pseudouridine synthase 1; May be responsible for synthesis of pseudouridine from uracil in transfer RNAs	0.753
MC1R	ATRNL1	ENSP00000451605	ENSP00000347152	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	0.630
MC1R	MC4R	ENSP00000451605	ENSP00000299766	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family	Melanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP); Belongs to the G-protein coupled receptor 1 family	0.938
MC1R	MGRN1	ENSP00000451605	ENSP00000262370	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family	E3 ubiquitin-protein ligase MGRN1; E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination; Ring finger proteins	0.770
MC4R	ATRNL1	ENSP00000299766	ENSP00000347152	Melanocortin receptor 4; Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP); Belongs to the G-protein coupled receptor 1 family	Attractin-like protein 1; May play a role in melanocortin signaling pathways that regulate energy homeostasis; C-type lectin domain containing	0.809

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