node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CGI-74 | PRPF39 | ENSP00000347005 | ENSP00000348010 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | 0.951 |
CGI-74 | PRPF40B | ENSP00000347005 | ENSP00000448073 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | 0.939 |
CGI-74 | SCNM1 | ENSP00000347005 | ENSP00000357901 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Sodium channel modifier 1; Plays a role in RNA splicing, possibly contributing to the recognition of non-consensus donor sites | 0.940 |
CGI-74 | SNRNP70 | ENSP00000347005 | ENSP00000472998 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA; RNA binding motif containing | 0.970 |
CGI-74 | SNRPC | ENSP00000347005 | ENSP00000244520 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | 0.953 |
CGI-74 | SNRPD2 | ENSP00000347005 | ENSP00000342374 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Small nuclear ribonucleoprotein Sm D2; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP | 0.958 |
CGI-74 | SNRPD3 | ENSP00000347005 | ENSP00000215829 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.918 |
CGI-74 | SNRPE | ENSP00000347005 | ENSP00000400591 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Small nuclear ribonucleoprotein E; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing. May indirectly play a role in hair development | 0.885 |
CGI-74 | SNRPF | ENSP00000347005 | ENSP00000266735 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Small nuclear ribonucleoprotein F; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.893 |
CGI-74 | SNRPG | ENSP00000347005 | ENSP00000272348 | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.887 |
PRPF39 | CGI-74 | ENSP00000348010 | ENSP00000347005 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.951 |
PRPF39 | PRPF40B | ENSP00000348010 | ENSP00000448073 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | 0.883 |
PRPF39 | SNRNP70 | ENSP00000348010 | ENSP00000472998 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | U1 small nuclear ribonucleoprotein 70 kDa; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRNP70 binds to the loop I region of U1-snRNA. The truncated isoforms cannot bind U1-snRNA; RNA binding motif containing | 0.967 |
PRPF39 | SNRPC | ENSP00000348010 | ENSP00000244520 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5’ splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5’ splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5’ splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5’ end of the U1 snRNA and the 5’ splice-site region; Belongs to the U1 [...] | 0.967 |
PRPF39 | SNRPD2 | ENSP00000348010 | ENSP00000342374 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Small nuclear ribonucleoprotein Sm D2; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP | 0.889 |
PRPF39 | SNRPD3 | ENSP00000348010 | ENSP00000215829 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Small nuclear ribonucleoprotein Sm D3; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.934 |
PRPF39 | SNRPE | ENSP00000348010 | ENSP00000400591 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Small nuclear ribonucleoprotein E; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing. May indirectly play a role in hair development | 0.858 |
PRPF39 | SNRPF | ENSP00000348010 | ENSP00000266735 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Small nuclear ribonucleoprotein F; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3’-end processing | 0.920 |
PRPF39 | SNRPG | ENSP00000348010 | ENSP00000272348 | Pre-mRNA-processing factor 39; Involved in pre-mRNA splicing; Belongs to the PRP39 family | Small nuclear ribonucleoprotein G; Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Appears to function in the U7 snRNP complex that is involved in histone 3’-end processing | 0.840 |
PRPF40B | CGI-74 | ENSP00000448073 | ENSP00000347005 | Pre-mRNA-processing factor 40 homolog B; May be involved in pre-mRNA splicing | Putative RNA-binding protein Luc7-like 2; May bind to RNA via its Arg/Ser-rich domain | 0.939 |