• Version:
  • 11.0 [archived version]
STRINGSTRING
KANK2 KANK2 LPPR2 LPPR2 CCDC159 CCDC159 KLHL29 KLHL29 SWSAP1 SWSAP1 RAB3D RAB3D MOXD1 MOXD1 TMEM205 TMEM205 VTI1B VTI1B MTMR11 MTMR11 OCEL1 OCEL1
"TMEM205" - Transmembrane protein 205 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
TMEM205Transmembrane protein 205; In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin (189 aa)    
Predicted Functional Partners:
SWSAP1
ATPase SWSAP1; ATPase which is preferentially stimulated by single- stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity; CTLH complex (229 aa)
           
  0.785
LPPR2
Lipid phosphate phosphatase-related protein type 2 (427 aa)
           
  0.671
CCDC159
Coiled-coil domain containing 159 (297 aa)
     
   
  0.651
OCEL1
occludin/ELL domain containing 1; Belongs to the ELL/occludin family (264 aa)
           
  0.650
KANK2
KN motif and ankyrin repeat domain-containing protein 2; Involved in transcription regulation by sequestering nuclear receptor coactivators, such as NCOA1, NCOA2 and NCOA3, in the cytoplasm; the function is deregulated by phosphorylation. Involved in the negative control of vitamin D receptor signaling pathway. May be involved in the control of cytoskeleton formation by regulating actin polymerization. Involved in regulation of caspase-independent apoptosis; proposed to sequester AIFM1 in mitochondria and apoptotic stimuli lead to its proteasomal degradation allowing the release of AIF [...] (859 aa)
           
  0.618
RAB3D
Ras-related protein Rab-3D; Protein transport. Probably involved in regulated exocytosis (By similarity); Belongs to the small GTPase superfamily. Rab family (219 aa)
 
 
   
  0.602
VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B; V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence; Belongs to the VTI1 family (232 aa)
           
  0.541
MOXD1
Monooxygenase DBH like 1; Belongs to the copper type II ascorbate-dependent monooxygenase family (613 aa)
           
  0.540
KLHL29
Kelch-like protein 29; Kelch like family member 29; BTB domain containing (875 aa)
           
  0.512
MTMR11
Myotubularin-related protein 11; Probable pseudophosphatase. Contains a Glu residue instead of a conserved Cys residue in the dsPTPase catalytic loop which renders it catalytically inactive as a phosphatase (Potential); Myotubularins (709 aa)
           
  0.512
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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