ACAP3 protein (human) - STRING database

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ACAP3

Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing (834 aa)

Predicted Functional Partners:

PUSL1

0.673

SCNN1D

0.649

C10orf11

0.605

DSTYK

0.579

MXI1

0.563

TXNL4B

0.559

TMEM105

0.557

RAB32

0.520

LENG8

0.509

SLC35E2B

0.507

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACAP3	C10orf11	ENSP00000346733	ENSP00000361577	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation	0.605
ACAP3	DSTYK	ENSP00000346733	ENSP00000356130	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types	0.579
ACAP3	LENG8	ENSP00000346733	ENSP00000318374	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Leukocyte receptor cluster member 8	0.509
ACAP3	MXI1	ENSP00000346733	ENSP00000331152	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins	0.563
ACAP3	PUSL1	ENSP00000346733	ENSP00000368318	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family	0.673
ACAP3	RAB32	ENSP00000346733	ENSP00000356465	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity); Belongs to the smal [...]	0.520
ACAP3	SCNN1D	ENSP00000346733	ENSP00000368411	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Amiloride-sensitive sodium channel subunit delta; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception	0.649
ACAP3	SLC35E2B	ENSP00000346733	ENSP00000481694	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Solute carrier family 35 member E2B; Putative transporter; Solute carriers	0.507
ACAP3	TMEM105	ENSP00000346733	ENSP00000329795	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Transmembrane protein 105	0.557
ACAP3	TXNL4B	ENSP00000346733	ENSP00000268483	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family	0.559
C10orf11	ACAP3	ENSP00000361577	ENSP00000346733	Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	0.605
C10orf11	RAB32	ENSP00000361577	ENSP00000356465	Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation	Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity); Belongs to the smal [...]	0.409
C10orf11	TXNL4B	ENSP00000361577	ENSP00000268483	Leucine-rich melanocyte differentiation-associated protein; Required for melanocyte differentiation	Thioredoxin-like protein 4B; Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition; Belongs to the DIM1 family	0.877
DSTYK	ACAP3	ENSP00000356130	ENSP00000346733	Dual serine/threonine and tyrosine protein kinase; Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death. In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	0.579
LENG8	ACAP3	ENSP00000318374	ENSP00000346733	Leukocyte receptor cluster member 8	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	0.509
MXI1	ACAP3	ENSP00000331152	ENSP00000346733	Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	0.563
MXI1	PUSL1	ENSP00000331152	ENSP00000368318	Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins	Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family	0.548
PUSL1	ACAP3	ENSP00000368318	ENSP00000346733	Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	0.673
PUSL1	MXI1	ENSP00000368318	ENSP00000331152	Pseudouridylate synthase-like 1; Belongs to the tRNA pseudouridine synthase TruA family	Max-interacting protein 1; Transcriptional repressor. MXI1 binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5’-CAC[GA]TG-3’. MXI1 thus antagonizes MYC transcriptional activity by competing for MAX; Basic helix-loop-helix proteins	0.548
RAB32	ACAP3	ENSP00000356465	ENSP00000346733	Ras-related protein Rab-32; Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays an important role in the control of melanin production and melanosome biogenesis. In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity); Belongs to the smal [...]	Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3; GTPase-activating protein for the ADP ribosylation factor family; Ankyrin repeat domain containing	0.520

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