RFPL1 protein (human) - STRING database

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Score

RFPL1

Ret finger protein like 1; Ring finger proteins (317 aa)

Predicted Functional Partners:

RFPL3S

0.906

NARS

0.756

RFPL3

0.693

NEFH

0.626

PAX6

0.594

FAM187B

0.586

GDF9

0.582

PRAMEF12

0.561

RASL10A

0.558

ZSCAN4

0.555

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
FAM187B	RFPL1	ENSP00000323355	ENSP00000346342	Protein FAM187B; Family with sequence similarity 187 member B	Ret finger protein like 1; Ring finger proteins	0.586
GDF9	RFPL1	ENSP00000367942	ENSP00000346342	Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells; [...]	Ret finger protein like 1; Ring finger proteins	0.582
NARS	RFPL1	ENSP00000256854	ENSP00000346342	Asparagine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II	Ret finger protein like 1; Ring finger proteins	0.756
NARS	RFPL3	ENSP00000256854	ENSP00000249007	Asparagine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II	Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex; Ring finger proteins	0.757
NARS	RFPL3S	ENSP00000256854	ENSP00000482492	Asparagine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II	Putative protein RFPL3S; RFPL3 antisense	0.800
NEFH	RFPL1	ENSP00000311997	ENSP00000346342	Neurofilament heavy polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins	Ret finger protein like 1; Ring finger proteins	0.626
PAX6	RFPL1	ENSP00000404100	ENSP00000346342	Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family	Ret finger protein like 1; Ring finger proteins	0.594
PAX6	RFPL3	ENSP00000404100	ENSP00000249007	Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family	Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex; Ring finger proteins	0.768
PRAMEF12	RFPL1	ENSP00000350358	ENSP00000346342	PRAME family member 12; Belongs to the PRAME family	Ret finger protein like 1; Ring finger proteins	0.561
PRAMEF12	RFPL3	ENSP00000350358	ENSP00000249007	PRAME family member 12; Belongs to the PRAME family	Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex; Ring finger proteins	0.448
PRAMEF12	ZSCAN4	ENSP00000350358	ENSP00000321963	PRAME family member 12; Belongs to the PRAME family	Zinc finger and SCAN domain-containing protein 4; Embryonic stem (ES) cell-specific transcription factor required to regulate ES cell pluripotency. Binds telomeres and plays a key role in genomic stability in ES cells by regulating telomere elongation. Acts as an activator of spontaneous telomere sister chromatid exchange (T-SCE) and telomere elongation in undifferentiated ES cells (By similarity); SCAN domain containing	0.573
RASL10A	RFPL1	ENSP00000216101	ENSP00000346342	Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family	Ret finger protein like 1; Ring finger proteins	0.558
RFPL1	FAM187B	ENSP00000346342	ENSP00000323355	Ret finger protein like 1; Ring finger proteins	Protein FAM187B; Family with sequence similarity 187 member B	0.586
RFPL1	GDF9	ENSP00000346342	ENSP00000367942	Ret finger protein like 1; Ring finger proteins	Growth/differentiation factor 9; Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells; [...]	0.582
RFPL1	NARS	ENSP00000346342	ENSP00000256854	Ret finger protein like 1; Ring finger proteins	Asparagine--tRNA ligase, cytoplasmic; Aminoacyl tRNA synthetases, Class II	0.756
RFPL1	NEFH	ENSP00000346342	ENSP00000311997	Ret finger protein like 1; Ring finger proteins	Neurofilament heavy polypeptide; Neurofilaments usually contain three intermediate filament proteins- L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins	0.626
RFPL1	PAX6	ENSP00000346342	ENSP00000404100	Ret finger protein like 1; Ring finger proteins	Paired box protein Pax-6; Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (By similarity). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Isoform 5a appears to function as a molecular switch that specifies target genes; Belongs to the paired homeobox family	0.594
RFPL1	PRAMEF12	ENSP00000346342	ENSP00000350358	Ret finger protein like 1; Ring finger proteins	PRAME family member 12; Belongs to the PRAME family	0.561
RFPL1	RASL10A	ENSP00000346342	ENSP00000216101	Ret finger protein like 1; Ring finger proteins	Ras-like protein family member 10A; Potent inhibitor of cellular proliferation; RAS type GTPase family	0.558
RFPL1	RFPL3	ENSP00000346342	ENSP00000249007	Ret finger protein like 1; Ring finger proteins	Ret finger protein-like 3; (Microbial infection) Stimulates the activity of Human Immunodeficiency Virus 1/HIV-1 pre-integration complex; Ring finger proteins	0.693

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