| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCKBR | PLEKHB1 | ENSP00000335544 | ENSP00000346127 | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.571 |
| CRX | PLEKHB1 | ENSP00000221996 | ENSP00000346127 | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.711 |
| DLK1 | MYCBP2 | ENSP00000340292 | ENSP00000444596 | Protein delta homolog 1; May have a role in neuroendocrine differentiation | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | 0.524 |
| DLK1 | PLEKHB1 | ENSP00000340292 | ENSP00000346127 | Protein delta homolog 1; May have a role in neuroendocrine differentiation | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.581 |
| GABBR1 | PLEKHB1 | ENSP00000366233 | ENSP00000346127 | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-depend [...] | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.609 |
| GABBR1 | PPT2 | ENSP00000366233 | ENSP00000354608 | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-depend [...] | Lysosomal thioesterase PPT2; Removes thioester-linked fatty acyl groups from various substrates including S-palmitoyl-CoA. Has the highest S- thioesterase activity for the acyl groups palmitic and myristic acid followed by other short- and long-chain acyl substrates. However, because of structural constraints, is unable to remove palmitate from peptides or proteins | 0.597 |
| HECA | PLEKHB1 | ENSP00000356630 | ENSP00000346127 | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.576 |
| HECA | SELPLG | ENSP00000356630 | ENSP00000228463 | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture; CD molecules | 0.669 |
| ICA1 | PLEKHB1 | ENSP00000385570 | ENSP00000346127 | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.575 |
| MYCBP2 | DLK1 | ENSP00000444596 | ENSP00000340292 | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | Protein delta homolog 1; May have a role in neuroendocrine differentiation | 0.524 |
| MYCBP2 | NMNAT1 | ENSP00000444596 | ENSP00000366410 | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | 0.755 |
| MYCBP2 | PLEKHB1 | ENSP00000444596 | ENSP00000346127 | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.739 |
| NMNAT1 | MYCBP2 | ENSP00000366410 | ENSP00000444596 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | E3 ubiquitin-protein ligase MYCBP2; E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of TSC2/tuberin. Interacts with the E2 enzymes UBE2D1, UBE2D3 and UBE2L3 (in vitro). May function as a facilitator or regulator of transcriptional activation by MYC. May have a role during synaptogenesis; Belongs to the highwire family | 0.755 |
| NMNAT1 | PLEKHB1 | ENSP00000366410 | ENSP00000346127 | Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less [...] | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | 0.622 |
| PLEKHB1 | CCKBR | ENSP00000346127 | ENSP00000335544 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Gastrin/cholecystokinin type B receptor; Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family | 0.571 |
| PLEKHB1 | CRX | ENSP00000346127 | ENSP00000221996 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Cone-rod homeobox protein; Transcription factor that binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors; Belongs to the paired homeobox family | 0.711 |
| PLEKHB1 | DLK1 | ENSP00000346127 | ENSP00000340292 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Protein delta homolog 1; May have a role in neuroendocrine differentiation | 0.581 |
| PLEKHB1 | GABBR1 | ENSP00000346127 | ENSP00000366233 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Gamma-aminobutyric acid type B receptor subunit 1; Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-depend [...] | 0.609 |
| PLEKHB1 | HECA | ENSP00000346127 | ENSP00000356630 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Headcase protein homolog; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | 0.576 |
| PLEKHB1 | ICA1 | ENSP00000346127 | ENSP00000385570 | Pleckstrin homology domain-containing family B member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation; Pleckstrin homology domain containing | Islet cell autoantigen 1; May play a role in neurotransmitter secretion; Classical BAR domain containing | 0.575 |
