• Version:
  • 11.0 [archived version]
STRINGSTRING
HFL3 HFL3 NOD2 NOD2 SPG7 SPG7 PGLYRP2 PGLYRP2 ENSG00000273155 ENSG00000273155 EVI5L EVI5L TMEM121 TMEM121 TXNDC9 TXNDC9 MITD1 MITD1 AKAP17A AKAP17A IDS IDS
"PGLYRP2" - N-acetylmuramoyl-L-alanine amidase in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PGLYRP2N-acetylmuramoyl-L-alanine amidase; May play a scavenger role by digesting biologically active peptidoglycan (PGN) into biologically inactive fragments. Has no direct bacteriolytic activity; Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family (576 aa)    
Predicted Functional Partners:
MITD1
MIT domain-containing protein 1; Required for efficient abscission at the end of cytokinesis, together with components of the ESCRT-III complex (249 aa)
           
  0.713
ENSG00000273155
annotation not available (131 aa)
           
  0.705
AKAP17A
A-kinase anchor protein 17A; Splice factor regulating alternative splice site selection for certain mRNA precursors. Mediates regulation of pre- mRNA splicing in a PKA-dependent manner; A-kinase anchoring proteins (695 aa)
     
   
  0.682
EVI5L
EVI5-like protein; Functions as a GTPase-activating protein (GAP) with a broad specificity (805 aa)
           
  0.678
TXNDC9
Thioredoxin domain-containing protein 9; Significantly diminishes the chaperonin TCP1 complex ATPase activity, thus negatively impacts protein folding, including that of actin or tubulin (226 aa)
           
  0.644
NOD2
Nucleotide-binding oligomerization domain-containing protein 2; Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3, INAVA and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macroph [...] (1040 aa)
     
   
  0.641
TMEM121
Transmembrane protein 121; May play a role in MAPK signaling; Belongs to the TMEM121 family (319 aa)
           
  0.626
SPG7
Paraplegin; ATP-dependent zinc metalloprotease. Plays a role in the formation and regulation of the mitochondrial permeability transition pore (mPTP) and its proteolytic activity is dispensable for this function; In the N-terminal section; belongs to the AAA ATPase family (795 aa)
           
  0.623
IDS
Iduronate 2-sulfatase; Required for the lysosomal degradation of heparan sulfate and dermatan sulfate; Sulfatases (550 aa)
           
  0.604
HFL3
Complement factor H-related protein 2; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism (270 aa)
     
   
  0.588
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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