node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BZRAP1 | PPFIA1 | ENSP00000345824 | ENSP00000253925 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | 0.933 |
BZRAP1 | PPFIA2 | ENSP00000345824 | ENSP00000450337 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Belongs to the liprin family. Liprin-alpha subfamily | 0.923 |
BZRAP1 | PPFIA3 | ENSP00000345824 | ENSP00000335614 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Liprin-alpha-3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Belongs to the liprin family. Liprin-alpha subfamily | 0.935 |
BZRAP1 | RAB3A | ENSP00000345824 | ENSP00000222256 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal; RAB, member RAS oncogene GTPases | 0.969 |
BZRAP1 | RIMS1 | ENSP00000345824 | ENSP00000428417 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes; PDZ domain containing | 0.983 |
BZRAP1 | RIMS2 | ENSP00000345824 | ENSP00000262231 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes; PDZ domain containing | 0.983 |
BZRAP1 | SNAP25 | ENSP00000345824 | ENSP00000254976 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.927 |
BZRAP1 | SYT1 | ENSP00000345824 | ENSP00000261205 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.938 |
BZRAP1 | TSPO | ENSP00000345824 | ENSP00000379563 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Translocator protein; Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism, but its precise physiological role is controversial. It is apparently not required for steroid hormone biosynthesis. Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides; Belongs to the TspO/BZRP family | 0.976 |
BZRAP1 | UNC13B | ENSP00000345824 | ENSP00000367756 | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | Protein unc-13 homolog B; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity); Belongs to the unc-13 family | 0.973 |
PPFIA1 | BZRAP1 | ENSP00000253925 | ENSP00000345824 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | 0.933 |
PPFIA1 | PPFIA2 | ENSP00000253925 | ENSP00000450337 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Belongs to the liprin family. Liprin-alpha subfamily | 0.922 |
PPFIA1 | PPFIA3 | ENSP00000253925 | ENSP00000335614 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Liprin-alpha-3; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Belongs to the liprin family. Liprin-alpha subfamily | 0.923 |
PPFIA1 | RAB3A | ENSP00000253925 | ENSP00000222256 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Ras-related protein Rab-3A; Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal; RAB, member RAS oncogene GTPases | 0.939 |
PPFIA1 | RIMS1 | ENSP00000253925 | ENSP00000428417 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Regulating synaptic membrane exocytosis protein 1; Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short- term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes; PDZ domain containing | 0.974 |
PPFIA1 | RIMS2 | ENSP00000253925 | ENSP00000262231 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Regulating synaptic membrane exocytosis protein 2; Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes; PDZ domain containing | 0.530 |
PPFIA1 | SNAP25 | ENSP00000253925 | ENSP00000254976 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Synaptosomal-associated protein 25; t-SNARE involved in the molecular regulation of neurotransmitter release. May play an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells; SNAREs | 0.935 |
PPFIA1 | SYT1 | ENSP00000253925 | ENSP00000261205 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Synaptotagmin-1; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes; Synaptotagmins | 0.937 |
PPFIA1 | UNC13B | ENSP00000253925 | ENSP00000367756 | Liprin-alpha-1; May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Sterile alpha motif domain containing | Protein unc-13 homolog B; Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity); Belongs to the unc-13 family | 0.976 |
PPFIA2 | BZRAP1 | ENSP00000450337 | ENSP00000345824 | Liprin-alpha-2; Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates; Belongs to the liprin family. Liprin-alpha subfamily | Benzodiazepine receptor (peripheral) associated protein 1; Belongs to the RIMBP family | 0.923 |