| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BEND6 | BEND7 | ENSP00000359782 | ENSP00000345773 | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing | BEN domain containing 7 | 0.866 |
| BEND6 | NACC1 | ENSP00000359782 | ENSP00000292431 | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing | 0.535 |
| BEND6 | NACC2 | ENSP00000359782 | ENSP00000277554 | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing | Nucleus accumbens-associated protein 2; Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53; BEN domain containing | 0.491 |
| BEND7 | BEND6 | ENSP00000345773 | ENSP00000359782 | BEN domain containing 7 | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing | 0.866 |
| BEND7 | MBD3 | ENSP00000345773 | ENSP00000412302 | BEN domain containing 7 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases; Methyl-CpG binding domain containing | 0.553 |
| BEND7 | MBD3L1 | ENSP00000345773 | ENSP00000471575 | BEN domain containing 7 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor | 0.677 |
| BEND7 | NACC1 | ENSP00000345773 | ENSP00000292431 | BEN domain containing 7 | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing | 0.585 |
| BEND7 | NACC2 | ENSP00000345773 | ENSP00000277554 | BEN domain containing 7 | Nucleus accumbens-associated protein 2; Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53; BEN domain containing | 0.557 |
| BEND7 | PGPEP1 | ENSP00000345773 | ENSP00000269919 | BEN domain containing 7 | Pyroglutamyl-peptidase 1; Removes 5-oxoproline from various penultimate amino acid residues except L-proline | 0.794 |
| BEND7 | PPM1B | ENSP00000345773 | ENSP00000282412 | BEN domain containing 7 | Protein phosphatase 1B; Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at ’Ser- 172’. Plays an important role in the termination of TNF-alpha- mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB; Belongs to the PP2C family | 0.695 |
| BEND7 | SMARCA2 | ENSP00000345773 | ENSP00000265773 | BEN domain containing 7 | Probable global transcription activator SNF2L2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural develop [...] | 0.539 |
| BEND7 | TRIM27 | ENSP00000345773 | ENSP00000366404 | BEN domain containing 7 | Zinc finger protein RFP; E3 ubiquitin-protein ligase that mediates ubiquitination of PIK3C2B and inhibits its activity; mediates the formation of ’Lys-48’-linked polyubiquitin chains; the function inhibits CD4 T- cell activation. Acts as a regulator of retrograde transport- together with MAGEL2, mediates the formation of ’Lys-63’-linked polyubiquitin chains at ’Lys-220’ of WASHC1, leading to promote endosomal F-actin assembly. Has a transcriptional repressor activity by cooperating with EPC1. Induces apoptosis by activating Jun N-terminal kinase and p38 kinase and also increases caspas [...] | 0.689 |
| BEND7 | ZNF219 | ENSP00000345773 | ENSP00000354206 | BEN domain containing 7 | Zinc finger protein 219; Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5’-GGGGG-3’. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulates SNCA expression in primary cortical neurons. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family | 0.564 |
| MBD3 | BEND7 | ENSP00000412302 | ENSP00000345773 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases; Methyl-CpG binding domain containing | BEN domain containing 7 | 0.553 |
| MBD3 | PGPEP1 | ENSP00000412302 | ENSP00000269919 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases; Methyl-CpG binding domain containing | Pyroglutamyl-peptidase 1; Removes 5-oxoproline from various penultimate amino acid residues except L-proline | 0.470 |
| MBD3 | ZNF219 | ENSP00000412302 | ENSP00000354206 | Methyl-CpG-binding domain protein 3; Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases; Methyl-CpG binding domain containing | Zinc finger protein 219; Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5’-GGGGG-3’. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulates SNCA expression in primary cortical neurons. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family | 0.570 |
| MBD3L1 | BEND7 | ENSP00000471575 | ENSP00000345773 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor | BEN domain containing 7 | 0.677 |
| MBD3L1 | ZNF219 | ENSP00000471575 | ENSP00000354206 | Methyl-CpG-binding domain protein 3-like 1; Transcriptional repressor | Zinc finger protein 219; Transcriptional regulator. Recognizes and binds 2 copies of the core DNA sequence motif 5’-GGGGG-3’. Binds to the HMGN1 promoter and may repress HMGN1 expression. Regulates SNCA expression in primary cortical neurons. Binds to the COL2A1 promoter and activates COL2A1 expression, as part of a complex with SOX9 (By similarity). Plays a role in chondrocyte differentiation (By similarity); Belongs to the krueppel C2H2-type zinc-finger protein family | 0.828 |
| NACC1 | BEND6 | ENSP00000292431 | ENSP00000359782 | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing | BEN domain-containing protein 6; Acts as a corepressor of recombining binding protein suppressor hairless (RBPJ) and inhibits Notch signaling in neural stem cells, thereby opposing their self-renewal and promoting neurogenesis; BEN domain containing | 0.535 |
| NACC1 | BEND7 | ENSP00000292431 | ENSP00000345773 | Nucleus accumbens-associated protein 1; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines; BEN domain containing | BEN domain containing 7 | 0.585 |
