• Version:
  • 11.0 [archived version]
STRINGSTRING
IRF8 IRF8 DDX41 DDX41 ZSCAN9 ZSCAN9 ZSCAN26 ZSCAN26 NKAPL NKAPL ZKSCAN4 ZKSCAN4 ZNF681 ZNF681 TSPAN18 TSPAN18 PIGH PIGH OR10K2 OR10K2 CIR1 CIR1
"NKAPL" - NKAP-like protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NKAPLNKAP-like protein; Transcriptional repressor of Notch-mediated signaling. Required for spermatogenesis (402 aa)    
Predicted Functional Partners:
CIR1
Corepressor interacting with RBPJ 1; May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (450 aa)
      
 
  0.842
ZKSCAN4
Zinc finger protein with KRAB and SCAN domains 4; May be involved in the transcriptional activation of MDM2 and EP300 genes; Belongs to the krueppel C2H2-type zinc-finger protein family (545 aa)
            
  0.736
OR10K2
Olfactory receptor 10K2; Odorant receptor; Olfactory receptors, family 10 (312 aa)
            
  0.669
ZSCAN9
Zinc finger and SCAN domain containing 9 (445 aa)
            
  0.651
PIGH
Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis (188 aa)
            
  0.622
ZSCAN26
Zinc finger and SCAN domain-containing protein 26; May be involved in transcriptional regulation; SCAN domain containing (344 aa)
            
  0.613
TSPAN18
Tetraspanin-18; Tetraspanin 18; Tetraspanins (248 aa)
            
  0.589
DDX41
Probable ATP-dependent RNA helicase DDX41; Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing; Belongs to the DEAD box helicase family. DDX41 subfamily (622 aa)
      
      0.572
ZNF681
Zinc finger protein 681; May be involved in transcriptional regulation; Zinc fingers C2H2-type (645 aa)
            
  0.559
IRF8
Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5’-TGAnTCA/GAAA-3’), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes [...] (426 aa)
            
  0.544
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
Server load: low (0%) [HD]
STRING is part of the ELIXIR infrastructure: it is one of ELIXIR's Core Data Resources.  Learn more >