node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CDX4 | CHIC1 | ENSP00000362613 | ENSP00000362601 | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | 0.726 |
CDX4 | RLIM | ENSP00000362613 | ENSP00000328059 | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.714 |
CDX4 | SLC16A2 | ENSP00000362613 | ENSP00000465734 | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family | 0.509 |
CDX4 | ZCCHC13 | ENSP00000362613 | ENSP00000345633 | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | Zinc finger CCHC-type containing 13 | 0.533 |
CHIC1 | CDX4 | ENSP00000362601 | ENSP00000362613 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | 0.726 |
CHIC1 | PDZRN3 | ENSP00000362601 | ENSP00000263666 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation; PDZ domain containing | 0.487 |
CHIC1 | RLIM | ENSP00000362601 | ENSP00000328059 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | 0.825 |
CHIC1 | SLC16A2 | ENSP00000362601 | ENSP00000465734 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family | 0.603 |
CHIC1 | ZCCHC13 | ENSP00000362601 | ENSP00000345633 | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | Zinc finger CCHC-type containing 13 | 0.670 |
FAM47B | SATL1 | ENSP00000328307 | ENSP00000425421 | Protein FAM47B; Family with sequence similarity 47 member B; Belongs to the FAM47 family | Spermidine/spermine N1-acetyl transferase like 1; GCN5 related N-acetyltransferases | 0.555 |
FAM47B | ZCCHC13 | ENSP00000328307 | ENSP00000345633 | Protein FAM47B; Family with sequence similarity 47 member B; Belongs to the FAM47 family | Zinc finger CCHC-type containing 13 | 0.531 |
PDZRN3 | CHIC1 | ENSP00000263666 | ENSP00000362601 | E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation; PDZ domain containing | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | 0.487 |
PDZRN3 | ZCCHC13 | ENSP00000263666 | ENSP00000345633 | E3 ubiquitin-protein ligase PDZRN3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation; PDZ domain containing | Zinc finger CCHC-type containing 13 | 0.509 |
PRRT3 | WBSCR27 | ENSP00000392511 | ENSP00000297873 | Proline rich transmembrane protein 3 | Methyltransferase-like protein 27; Williams Beuren syndrome chromosome region 27 | 0.703 |
PRRT3 | ZCCHC13 | ENSP00000392511 | ENSP00000345633 | Proline rich transmembrane protein 3 | Zinc finger CCHC-type containing 13 | 0.560 |
RLIM | CDX4 | ENSP00000328059 | ENSP00000362613 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | Homeobox protein CDX-4; HOXL subclass homeoboxes; Belongs to the Caudal homeobox family | 0.714 |
RLIM | CHIC1 | ENSP00000328059 | ENSP00000362601 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | Cysteine-rich hydrophobic domain-containing protein 1; Armadillo-like helical domain containing; Belongs to the CHIC family | 0.825 |
RLIM | SLC16A2 | ENSP00000328059 | ENSP00000465734 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family | 0.516 |
RLIM | ZCCHC13 | ENSP00000328059 | ENSP00000345633 | E3 ubiquitin-protein ligase RLIM; E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of [...] | Zinc finger CCHC-type containing 13 | 0.578 |
SATL1 | FAM47B | ENSP00000425421 | ENSP00000328307 | Spermidine/spermine N1-acetyl transferase like 1; GCN5 related N-acetyltransferases | Protein FAM47B; Family with sequence similarity 47 member B; Belongs to the FAM47 family | 0.555 |