ZNF587 protein (human) - STRING database

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ZNF587

Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (575 aa)

Predicted Functional Partners:

TRIM28

0.922

CYSRT1

0.485

ZFAND4

0.457

LRRC66

0.447

RUNX2

0.435

ZC3H6

0.428

PCDHA9

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYSRT1	ZNF587	ENSP00000386453	ENSP00000345479	Cysteine rich tail 1	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.485
LRRC66	ZFAND4	ENSP00000341944	ENSP00000339484	Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66	Zinc finger AN1-type containing 4	0.623
LRRC66	ZNF587	ENSP00000341944	ENSP00000345479	Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.447
PCDHA9	ZNF587	ENSP00000436042	ENSP00000345479	Protocadherin alpha-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.405
RUNX2	ZNF587	ENSP00000360493	ENSP00000345479	Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation- synergizes with SPEN/MINT to enhance FGFR2-mediat [...]	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.435
TRIM28	ZNF587	ENSP00000253024	ENSP00000345479	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.922
ZC3H6	ZNF587	ENSP00000386764	ENSP00000345479	Zinc finger CCCH-type containing 6	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.428
ZFAND4	LRRC66	ENSP00000339484	ENSP00000341944	Zinc finger AN1-type containing 4	Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66	0.623
ZFAND4	ZNF587	ENSP00000339484	ENSP00000345479	Zinc finger AN1-type containing 4	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	0.457
ZNF587	CYSRT1	ENSP00000345479	ENSP00000386453	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Cysteine rich tail 1	0.485
ZNF587	LRRC66	ENSP00000345479	ENSP00000341944	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Leucine-rich repeat-containing protein 66; Leucine rich repeat containing 66	0.447
ZNF587	PCDHA9	ENSP00000345479	ENSP00000436042	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Protocadherin alpha-9; Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain; Clustered protocadherins	0.405
ZNF587	RUNX2	ENSP00000345479	ENSP00000360493	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation- synergizes with SPEN/MINT to enhance FGFR2-mediat [...]	0.435
ZNF587	TRIM28	ENSP00000345479	ENSP00000253024	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...]	0.922
ZNF587	ZC3H6	ENSP00000345479	ENSP00000386764	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Zinc finger CCCH-type containing 6	0.428
ZNF587	ZFAND4	ENSP00000345479	ENSP00000339484	Zinc finger protein 587; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family	Zinc finger AN1-type containing 4	0.457

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