| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSL4 | ASCL4 | ENSP00000339787 | ENSP00000345420 | Long-chain-fatty-acid--CoA ligase 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates; Acyl-CoA synthetase family | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | 0.540 |
| ADAT1 | ASCL4 | ENSP00000310015 | ENSP00000345420 | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | 0.517 |
| ADAT1 | ASXL3 | ENSP00000310015 | ENSP00000269197 | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | 0.403 |
| ADAT1 | GPATCH1 | ENSP00000310015 | ENSP00000170564 | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA | G-patch domain containing 1; Belongs to the GPATCH1 family | 0.599 |
| ADAT1 | TMEM231 | ENSP00000310015 | ENSP00000258173 | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) | 0.443 |
| ASCL4 | ACSL4 | ENSP00000345420 | ENSP00000339787 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | Long-chain-fatty-acid--CoA ligase 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates; Acyl-CoA synthetase family | 0.540 |
| ASCL4 | ADAT1 | ENSP00000345420 | ENSP00000310015 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA | 0.517 |
| ASCL4 | ASXL3 | ENSP00000345420 | ENSP00000269197 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | 0.482 |
| ASCL4 | FOXP1 | ENSP00000345420 | ENSP00000484803 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of s [...] | 0.436 |
| ASCL4 | GPATCH1 | ENSP00000345420 | ENSP00000170564 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | G-patch domain containing 1; Belongs to the GPATCH1 family | 0.678 |
| ASCL4 | GPATCH2 | ENSP00000345420 | ENSP00000355902 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing | 0.514 |
| ASCL4 | NADSYN1 | ENSP00000345420 | ENSP00000326424 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | Glutamine-dependent NAD(+) synthetase; NAD synthetase 1; In the C-terminal section; belongs to the NAD synthetase family | 0.451 |
| ASCL4 | PRKAA1 | ENSP00000345420 | ENSP00000346148 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | 5’-AMP-activated protein kinase catalytic subunit alpha-1; Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes- inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts a [...] | 0.430 |
| ASCL4 | TCF12 | ENSP00000345420 | ENSP00000388940 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | Transcription factor 12; Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5’-CANNTG-3’); Basic helix-loop-helix proteins | 0.537 |
| ASCL4 | TMEM231 | ENSP00000345420 | ENSP00000258173 | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | Transmembrane protein 231; Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity) | 0.513 |
| ASXL3 | ADAT1 | ENSP00000269197 | ENSP00000310015 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | tRNA-specific adenosine deaminase 1; Specifically deaminates adenosine-37 to inosine in tRNA- Ala; Adenosine deaminases acting on RNA | 0.403 |
| ASXL3 | ASCL4 | ENSP00000269197 | ENSP00000345420 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | 0.482 |
| ASXL3 | GPATCH1 | ENSP00000269197 | ENSP00000170564 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | G-patch domain containing 1; Belongs to the GPATCH1 family | 0.547 |
| ASXL3 | GPATCH2 | ENSP00000269197 | ENSP00000355902 | Putative Polycomb group protein ASXL3; Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility (By similarity) | G patch domain-containing protein 2; Enhances the ATPase activity of DHX15 in vitro; G-patch domain containing | 0.403 |
| FOXP1 | ASCL4 | ENSP00000484803 | ENSP00000345420 | Forkhead box protein P1; Transcriptional repressor. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of s [...] | Achaete-scute homolog 4; Could be a transcriptional regulator involved in skin development; Basic helix-loop-helix proteins | 0.436 |
