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STRINGSTRING
USP4 USP4 ANP32E ANP32E MOCS1 MOCS1 R3HCC1 R3HCC1 THOP1 THOP1 FAM149A FAM149A PAPLN PAPLN EPHX4 EPHX4 CRCT1 CRCT1 THSD1 THSD1 SPARC SPARC
"PAPLN" - Papilin, proteoglycan like sulfated glycoprotein in Homo sapiens
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PAPLNPapilin, proteoglycan like sulfated glycoprotein; Belongs to the papilin family (1251 aa)    
Predicted Functional Partners:
SPARC
SPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity; SPARC family (303 aa)
      
   
  0.922
ANP32E
Acidic leucine-rich nuclear phosphoprotein 32 family member E; Histone chaperone that specifically mediates the genome- wide removal of histone H2A.Z/H2AFZ from the nucleosome- removes H2A.Z/H2AFZ from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AFZ in the nucleosome. May stabilize the evicted H2A.Z/H2AFZ-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebella [...] (268 aa)
            
  0.576
EPHX4
Epoxide hydrolase 4; Abhydrolase domain containing (362 aa)
            
  0.561
USP4
Ubiquitin carboxyl-terminal hydrolase 4; Hydrolase that deubiquitinates target proteins such as the receptor ADORA2A, PDPK1 and TRIM21. Deubiquitination of ADORA2A increases the amount of functional receptor at the cell surface. May regulate mRNA splicing through deubiquitination of the U4 spliceosomal protein PRPF3. This may prevent its recognition by the U5 component PRPF8 thereby destabilizing interactions within the U4/U6.U5 snRNP. May also play a role in the regulation of quality control in the ER; Ubiquitin specific peptidases (963 aa)
      
   
  0.553
THSD1
Thrombospondin type-1 domain-containing protein 1; Thrombospondin type 1 domain containing 1 (852 aa)
      
   
  0.552
R3HCC1
R3H domain and coiled-coil containing 1 (253 aa)
            
  0.543
FAM149A
Protein FAM149A; Family with sequence similarity 149 member A (482 aa)
            
  0.540
THOP1
Thimet oligopeptidase; Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments; M3 metallopeptidases (689 aa)
        
      0.540
CRCT1
Cysteine rich C-terminal 1 (99 aa)
            
  0.531
MOCS1
Molybdenum cofactor biosynthesis protein 1; Isoform MOCS1A and isoform MOCS1B probably form a complex that catalyzes the conversion of 5’-GTP to cyclic pyranopterin monophosphate (cPMP). MOCS1A catalyzes the cyclization of GTP to (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’- triphosphate and MOCS1B catalyzes the subsequent conversion of (8S)-3’,8-cyclo-7,8-dihydroguanosine 5’-triphosphate to cPMP; In the N-terminal section; belongs to the radical SAM superfamily. MoaA family (385 aa)
            
  0.528
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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