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  • 11.0 [archived version]
STRINGSTRING
CCDC130 CCDC130 C19orf53 C19orf53 ZSWIM4 ZSWIM4 C19orf57 C19orf57 C19orf67 C19orf67 DCAF15 DCAF15 LPHN1 LPHN1 PODNL1 PODNL1 LPHN3 LPHN3 ADAMTS4 ADAMTS4 LPHN2 LPHN2
"PODNL1" - Podocan-like protein 1 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
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[Homology]
Score
PODNL1Podocan-like protein 1; Podocan like 1 (512 aa)    
Predicted Functional Partners:
LPHN1
Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity) (1474 aa)
     
 
  0.764
LPHN3
Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily (1469 aa)
     
      0.685
LPHN2
Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily (1403 aa)
     
      0.685
C19orf57
Uncharacterized protein C19orf57; Chromosome 19 open reading frame 57 (637 aa)
 
       
  0.665
C19orf67
UPF0575 protein C19orf67; Chromosome 19 open reading frame 67; Belongs to the UPF0575 family (358 aa)
           
  0.658
C19orf53
Leydig cell tumor 10 kDa protein homolog; May have a potential role in hypercalcemia of malignancy (99 aa)
           
  0.559
DCAF15
DDB1- and CUL4-associated factor 15; May be involved in ubiquitination and degradation through a DBB1-CUL4 E3 protein-ubiquitin ligase; DDB1 and CUL4 associated factors (600 aa)
           
  0.525
ADAMTS4
A disintegrin and metalloproteinase with thrombospondin motifs 4; Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the ’392-Glu-|-Ala-393’ site; ADAM metallopeptidases with thrombospondin type 1 motif (837 aa)
           
  0.473
ZSWIM4
Zinc finger SWIM-type containing 4 (989 aa)
           
  0.473
CCDC130
Coiled-coil domain containing 130; Belongs to the CWC16 family (396 aa)
     
 
  0.460
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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