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  • 11.0 [archived version]
STRINGSTRING
MCF2L2 MCF2L2 C12orf74 C12orf74 ARHGEF39 ARHGEF39 CLLU1 CLLU1 ARHGEF4 ARHGEF4 PLEKHG7 PLEKHG7 PLEKHG2 PLEKHG2 LASP1 LASP1 ARHGEF40 ARHGEF40 VPS4A VPS4A PLEKHG4B PLEKHG4B
"PLEKHG7" - Pleckstrin homology and RhoGEF domain containing G7 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
PLEKHG7Pleckstrin homology and RhoGEF domain containing G7 (379 aa)    
Predicted Functional Partners:
PLEKHG4B
Pleckstrin homology and RhoGEF domain containing G4B (1271 aa)
           
  0.794
MCF2L2
Probable guanine nucleotide exchange factor MCF2L2; Probably functions as a guanine nucleotide exchange factor; Belongs to the MCF2 family (1114 aa)
           
  0.794
C12orf74
Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 (190 aa)
 
            0.595
CLLU1
Chronic lymphocytic leukemia up-regulated 1 (121 aa)
           
  0.543
ARHGEF4
Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing (690 aa)
     
 
  0.540
VPS4A
Vacuolar protein sorting-associated protein 4A; Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth fact [...] (437 aa)
           
  0.537
ARHGEF39
Rho guanine nucleotide exchange factor 39; Promotes cell proliferation (335 aa)
           
  0.534
LASP1
LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing (261 aa)
     
   
  0.511
PLEKHG2
Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). Involved in the regulation of actin polymerization; Pleckstrin homology domain containing (1386 aa)
           
  0.500
ARHGEF40
Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) (1519 aa)
           
  0.493
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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