node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF39 | ARHGEF4 | ENSP00000367638 | ENSP00000316845 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing | 0.649 |
ARHGEF39 | MCF2L2 | ENSP00000367638 | ENSP00000328118 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | Probable guanine nucleotide exchange factor MCF2L2; Probably functions as a guanine nucleotide exchange factor; Belongs to the MCF2 family | 0.442 |
ARHGEF39 | PLEKHG7 | ENSP00000367638 | ENSP00000344961 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | Pleckstrin homology and RhoGEF domain containing G7 | 0.534 |
ARHGEF4 | ARHGEF39 | ENSP00000316845 | ENSP00000367638 | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | 0.649 |
ARHGEF4 | ARHGEF40 | ENSP00000316845 | ENSP00000298694 | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) | 0.426 |
ARHGEF4 | PLEKHG7 | ENSP00000316845 | ENSP00000344961 | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing | Pleckstrin homology and RhoGEF domain containing G7 | 0.540 |
ARHGEF40 | ARHGEF4 | ENSP00000298694 | ENSP00000316845 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing | 0.426 |
ARHGEF40 | PLEKHG2 | ENSP00000298694 | ENSP00000392906 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) | Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). Involved in the regulation of actin polymerization; Pleckstrin homology domain containing | 0.490 |
ARHGEF40 | PLEKHG7 | ENSP00000298694 | ENSP00000344961 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) | Pleckstrin homology and RhoGEF domain containing G7 | 0.493 |
C12orf74 | PLEKHG7 | ENSP00000380933 | ENSP00000344961 | Uncharacterized protein C12orf74; Chromosome 12 open reading frame 74 | Pleckstrin homology and RhoGEF domain containing G7 | 0.595 |
CLLU1 | PLEKHG7 | ENSP00000367746 | ENSP00000344961 | Chronic lymphocytic leukemia up-regulated 1 | Pleckstrin homology and RhoGEF domain containing G7 | 0.543 |
LASP1 | PLEKHG7 | ENSP00000325240 | ENSP00000344961 | LIM and SH3 domain protein 1; Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity); LIM domain containing | Pleckstrin homology and RhoGEF domain containing G7 | 0.511 |
MCF2L2 | ARHGEF39 | ENSP00000328118 | ENSP00000367638 | Probable guanine nucleotide exchange factor MCF2L2; Probably functions as a guanine nucleotide exchange factor; Belongs to the MCF2 family | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | 0.442 |
MCF2L2 | PLEKHG7 | ENSP00000328118 | ENSP00000344961 | Probable guanine nucleotide exchange factor MCF2L2; Probably functions as a guanine nucleotide exchange factor; Belongs to the MCF2 family | Pleckstrin homology and RhoGEF domain containing G7 | 0.794 |
PLEKHG2 | ARHGEF40 | ENSP00000392906 | ENSP00000298694 | Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). Involved in the regulation of actin polymerization; Pleckstrin homology domain containing | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) | 0.490 |
PLEKHG2 | PLEKHG7 | ENSP00000392906 | ENSP00000344961 | Pleckstrin homology domain-containing family G member 2; May be a transforming oncogene with exchange activity for CDC42 (By similarity). May be a guanine-nucleotide exchange factor (GEF) for RAC1 and CDC42. Activated by the binding to subunits beta and gamma of the heterotrimeric guanine nucleotide- binding protein (G protein). Involved in the regulation of actin polymerization; Pleckstrin homology domain containing | Pleckstrin homology and RhoGEF domain containing G7 | 0.500 |
PLEKHG4B | PLEKHG7 | ENSP00000283426 | ENSP00000344961 | Pleckstrin homology and RhoGEF domain containing G4B | Pleckstrin homology and RhoGEF domain containing G7 | 0.794 |
PLEKHG7 | ARHGEF39 | ENSP00000344961 | ENSP00000367638 | Pleckstrin homology and RhoGEF domain containing G7 | Rho guanine nucleotide exchange factor 39; Promotes cell proliferation | 0.534 |
PLEKHG7 | ARHGEF4 | ENSP00000344961 | ENSP00000316845 | Pleckstrin homology and RhoGEF domain containing G7 | Rho guanine nucleotide exchange factor 4; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression; Pleckstrin homology domain containing | 0.540 |
PLEKHG7 | ARHGEF40 | ENSP00000344961 | ENSP00000298694 | Pleckstrin homology and RhoGEF domain containing G7 | Rho guanine nucleotide exchange factor 40; May act as a guanine nucleotide exchange factor (GEF) | 0.493 |