DPY19L3 protein (human) - STRING database

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
some 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

DPY19L3

Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family (716 aa)

Predicted Functional Partners:

KBTBD11

0.687

BTBD16

0.644

CEP104

0.582

KIAA0930

0.581

UNC5A

0.578

USP6NL

0.573

PIGH

0.572

ZNF532

0.562

RSPO3

0.551

MBOAT2

0.532

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but resolution at 400 dpi

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as simple tabular text output:

download

TSV: tab separated values - can be opened in Excel

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and annotated functions of the network proteins

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTBD16	DPY19L3	ENSP00000260723	ENSP00000344937	BTB/POZ domain-containing protein 16; BTB domain containing 16	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	0.644
CEP104	DPY19L3	ENSP00000367476	ENSP00000344937	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	0.582
CEP104	KIAA0930	ENSP00000367476	ENSP00000251993	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	Uncharacterized protein KIAA0930; KIAA0930	0.541
CEP104	PIGH	ENSP00000367476	ENSP00000216452	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis	0.559
CEP104	USP6NL	ENSP00000367476	ENSP00000277575	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex	0.553
DPY19L3	BTBD16	ENSP00000344937	ENSP00000260723	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	BTB/POZ domain-containing protein 16; BTB domain containing 16	0.644
DPY19L3	CEP104	ENSP00000344937	ENSP00000367476	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	0.582
DPY19L3	KBTBD11	ENSP00000344937	ENSP00000321544	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Kelch repeat and BTB domain containing 11	0.687
DPY19L3	KIAA0930	ENSP00000344937	ENSP00000251993	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Uncharacterized protein KIAA0930; KIAA0930	0.581
DPY19L3	MBOAT2	ENSP00000344937	ENSP00000302177	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Lysophospholipid acyltransferase 2; Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling [...]	0.532
DPY19L3	PIGH	ENSP00000344937	ENSP00000216452	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Phosphatidylinositol N-acetylglucosaminyltransferase subunit H; Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis	0.572
DPY19L3	RSPO3	ENSP00000344937	ENSP00000349131	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	R-spondin-3; Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta- catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts [...]	0.551
DPY19L3	UNC5A	ENSP00000344937	ENSP00000332737	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Netrin receptor UNC5A; Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand; I-set domain containing	0.578
DPY19L3	USP6NL	ENSP00000344937	ENSP00000277575	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	USP6 N-terminal-like protein; Acts as a GTPase-activating protein for RAB5A and RAB43. Involved in receptor trafficking. In complex with EPS8 inhibits internalization of EGFR. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Required for structural integrity of the Golgi complex	0.573
DPY19L3	ZNF532	ENSP00000344937	ENSP00000338217	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.562
KBTBD11	DPY19L3	ENSP00000321544	ENSP00000344937	Kelch repeat and BTB domain containing 11	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	0.687
KBTBD11	MBOAT2	ENSP00000321544	ENSP00000302177	Kelch repeat and BTB domain containing 11	Lysophospholipid acyltransferase 2; Acyltransferase which mediates the conversion of lysophosphatidylethanolamine (1-acyl-sn-glycero-3- phosphoethanolamine or LPE) into phosphatidylethanolamine (1,2- diacyl-sn-glycero-3-phosphoethanolamine or PE) (LPEAT activity). Catalyzes also the acylation of lysophosphatidic acid (LPA) into phosphatidic acid (PA) (LPAAT activity). Has also a very weak lysophosphatidylcholine acyltransferase (LPCAT activity). Prefers oleoyl-CoA as the acyl donor. Lysophospholipid acyltransferases (LPLATs) catalyze the reacylation step of the phospholipid remodeling [...]	0.492
KBTBD11	ZNF532	ENSP00000321544	ENSP00000338217	Kelch repeat and BTB domain containing 11	Zinc finger protein 532; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.517
KIAA0930	CEP104	ENSP00000251993	ENSP00000367476	Uncharacterized protein KIAA0930; KIAA0930	Centrosomal protein of 104 kDa; Required for ciliogenesis and for structural integrity at the ciliary tip	0.541
KIAA0930	DPY19L3	ENSP00000251993	ENSP00000344937	Uncharacterized protein KIAA0930; KIAA0930	Probable C-mannosyltransferase DPY19L3; Probable C-mannosyltransferase that mediates C- mannosylation of tryptophan residues on target proteins; Belongs to the dpy-19 family	0.581

page 1 of 2

Network

Cooccurrence

Experiments

Coexpression

Textmining

Neighborhood

Databases

Fusion

© STRING Consortium 2020

Credits

Access

Info

About