• Version:
  • 11.0 [archived version]
STRINGSTRING
BPIFA1 BPIFA1 BPIFB1 BPIFB1 BPIFA2 BPIFA2 BPIFA3 BPIFA3 LHX3 LHX3 BPIFB6 BPIFB6 GHRHR GHRHR SUN5 SUN5 TSHB TSHB COMMD7 COMMD7 CGA CGA
"BPIFB6" - BPI fold containing family B member 6 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
BPIFB6BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family (453 aa)    
Predicted Functional Partners:
BPIFA3
BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (254 aa)
     
   
  0.802
BPIFA1
BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...] (256 aa)
     
   
  0.688
BPIFB1
BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (484 aa)
           
  0.681
BPIFA2
BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family (249 aa)
     
   
  0.621
SUN5
SUN domain-containing protein 5; May be involved in meiotic stage of spermatogenesis (379 aa)
     
   
  0.581
COMMD7
COMM domain-containing protein 7; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity (200 aa)
           
  0.518
TSHB
Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands (138 aa)
     
   
  0.514
LHX3
LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1; LIM class homeoboxes (402 aa)
     
        0.512
GHRHR
Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family (423 aa)
     
        0.512
CGA
Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family (147 aa)
     
        0.511
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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