node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPIFA1 | BPIFB1 | ENSP00000346251 | ENSP00000253354 | BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...] | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.418 |
BPIFA1 | BPIFB6 | ENSP00000346251 | ENSP00000344929 | BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...] | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.688 |
BPIFA2 | BPIFA3 | ENSP00000253362 | ENSP00000364603 | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.676 |
BPIFA2 | BPIFB1 | ENSP00000253362 | ENSP00000253354 | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.738 |
BPIFA2 | BPIFB6 | ENSP00000253362 | ENSP00000344929 | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.621 |
BPIFA3 | BPIFA2 | ENSP00000364603 | ENSP00000253362 | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.676 |
BPIFA3 | BPIFB1 | ENSP00000364603 | ENSP00000253354 | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.723 |
BPIFA3 | BPIFB6 | ENSP00000364603 | ENSP00000344929 | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.802 |
BPIFA3 | COMMD7 | ENSP00000364603 | ENSP00000278980 | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | COMM domain-containing protein 7; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity | 0.518 |
BPIFA3 | SUN5 | ENSP00000364603 | ENSP00000348496 | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | SUN domain-containing protein 5; May be involved in meiotic stage of spermatogenesis | 0.585 |
BPIFB1 | BPIFA1 | ENSP00000253354 | ENSP00000346251 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...] | 0.418 |
BPIFB1 | BPIFA2 | ENSP00000253354 | ENSP00000253362 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.738 |
BPIFB1 | BPIFA3 | ENSP00000253354 | ENSP00000364603 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.723 |
BPIFB1 | BPIFB6 | ENSP00000253354 | ENSP00000344929 | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | 0.681 |
BPIFB6 | BPIFA1 | ENSP00000344929 | ENSP00000346251 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | BPI fold-containing family A member 1; Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Binds bacterial lipopolysaccharide (LPS). Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory [...] | 0.688 |
BPIFB6 | BPIFA2 | ENSP00000344929 | ENSP00000253362 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | BPI fold-containing family A member 2; Has strong antibacterial activity against P. aeruginosa; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.621 |
BPIFB6 | BPIFA3 | ENSP00000344929 | ENSP00000364603 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | BPI fold containing family A member 3; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.802 |
BPIFB6 | BPIFB1 | ENSP00000344929 | ENSP00000253354 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | BPI fold-containing family B member 1; May play a role in innate immunity in mouth, nose and lungs. Binds bacterial lipopolysaccharide (LPS) and modulates the cellular responses to LPS; Belongs to the BPI/LBP/Plunc superfamily. Plunc family | 0.681 |
BPIFB6 | CGA | ENSP00000344929 | ENSP00000482232 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.511 |
BPIFB6 | COMMD7 | ENSP00000344929 | ENSP00000278980 | BPI fold containing family B member 6; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | COMM domain-containing protein 7; May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes. Associates with the NF-kappa-B complex and suppresses its transcriptional activity | 0.518 |