| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACSS1 | CST9 | ENSP00000316924 | ENSP00000366170 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | 0.626 |
| ACSS1 | CSTL1 | ENSP00000316924 | ENSP00000344907 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Cystatin-like 1; Cystatins, type 2 | 0.705 |
| ACSS1 | GZF1 | ENSP00000316924 | ENSP00000338290 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.701 |
| ACSS1 | NXT1 | ENSP00000316924 | ENSP00000254998 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.653 |
| ACSS1 | NXT2 | ENSP00000316924 | ENSP00000218004 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export | 0.623 |
| ACSS1 | TPM3 | ENSP00000316924 | ENSP00000357516 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family | 0.512 |
| CST9 | ACSS1 | ENSP00000366170 | ENSP00000316924 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.626 |
| CST9 | CSTL1 | ENSP00000366170 | ENSP00000344907 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | Cystatin-like 1; Cystatins, type 2 | 0.731 |
| CST9 | GZF1 | ENSP00000366170 | ENSP00000338290 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.513 |
| CST9 | NXT1 | ENSP00000366170 | ENSP00000254998 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.511 |
| CSTL1 | ACSS1 | ENSP00000344907 | ENSP00000316924 | Cystatin-like 1; Cystatins, type 2 | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.705 |
| CSTL1 | CST9 | ENSP00000344907 | ENSP00000366170 | Cystatin-like 1; Cystatins, type 2 | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | 0.731 |
| CSTL1 | GZF1 | ENSP00000344907 | ENSP00000338290 | Cystatin-like 1; Cystatins, type 2 | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.712 |
| CSTL1 | NUTF2 | ENSP00000344907 | ENSP00000219169 | Cystatin-like 1; Cystatins, type 2 | Nuclear transport factor 2; Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import | 0.470 |
| CSTL1 | NXT1 | ENSP00000344907 | ENSP00000254998 | Cystatin-like 1; Cystatins, type 2 | NTF2-related export protein 1; Stimulator of protein export for NES-containing proteins. Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA. The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 | 0.859 |
| CSTL1 | NXT2 | ENSP00000344907 | ENSP00000218004 | Cystatin-like 1; Cystatins, type 2 | NTF2-related export protein 2; Regulator of protein export for NES-containing proteins. Also plays a role in mRNA nuclear export | 0.453 |
| CSTL1 | PRAF2 | ENSP00000344907 | ENSP00000451962 | Cystatin-like 1; Cystatins, type 2 | PRA1 family protein 2; May be involved in ER/Golgi transport and vesicular traffic. Plays a proapoptic role in cerulenin-induced neuroblastoma apoptosis; YIP family | 0.518 |
| CSTL1 | TPM3 | ENSP00000344907 | ENSP00000357516 | Cystatin-like 1; Cystatins, type 2 | Tropomyosin alpha-3 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family | 0.561 |
| GZF1 | ACSS1 | ENSP00000338290 | ENSP00000316924 | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | Acetyl-coenzyme A synthetase 2-like, mitochondrial; Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2); Belongs to the ATP-dependent AMP-binding enzyme family | 0.701 |
| GZF1 | CST9 | ENSP00000338290 | ENSP00000366170 | GDNF-inducible zinc finger protein 1; Transcriptional repressor. Binds the GZF1 responsive element (GRE) (consensus- 5’-TGCGCN[TG][CA]TATA-3’). May be regulating VSX2/HOX10 expression; Belongs to the krueppel C2H2-type zinc-finger protein family | Cystatin-9; May be involved in testis development (By similarity). May play a role in hematopoietic differentiation or inflammation. Has immunomodulatory and antimicrobial functions against Francisella tularensis, a Gram-negative bacteria; Belongs to the cystatin family | 0.513 |
