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STRINGSTRING
RNF112 RNF112 TMEM243 TMEM243 CROT CROT DMTF1 DMTF1 RUNDC3B RUNDC3B DBF4 DBF4 SMIM1 SMIM1 SLC25A40 SLC25A40 DLGAP3 DLGAP3 SLC46A3 SLC46A3 PLLP PLLP
"SLC25A40" - Solute carrier family 25 member 40 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
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Textmining
[Homology]
Score
SLC25A40Solute carrier family 25 member 40 (338 aa)    
Predicted Functional Partners:
RUNDC3B
RUN domain containing 3B (473 aa)
      
   
  0.743
TMEM243
Transmembrane protein 243; Belongs to the TMEM243 family (118 aa)
            
  0.641
DLGAP3
Disks large-associated protein 3; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane; Belongs to the SAPAP family (979 aa)
            
  0.609
CROT
Peroxisomal carnitine O-octanoyltransferase; Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. Converts the end product of pristanic acid beta oxidation, 4,8-dimethylnonanoyl- CoA, to its corresponding carnitine ester; Belongs to the carnitine/choline acetyltransferase family (640 aa)
            
  0.593
SLC46A3
Solute carrier family 46 member 3; Belongs to the major facilitator superfamily. SLC46A family (463 aa)
      
   
  0.522
DBF4
Protein DBF4 homolog A; Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at ’Ser-40’ and ’Ser-53’ and then is involved in regulating the initiation of DNA replication during cell cycle; Zinc fingers DBF-type (674 aa)
      
   
  0.511
DMTF1
Cyclin-D-binding Myb-like transcription factor 1; Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5’-CCCG[GT]ATGT-3’ (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1; Myb/SANT domain containing (760 aa)
      
   
  0.475
RNF112
Ring finger protein 112 (631 aa)
            
  0.464
SMIM1
Small integral membrane protein 1; Regulator of red blood cell formation; Belongs to the SMIM1 family (78 aa)
            
  0.461
PLLP
Plasmolipin; Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K(+)-selective (By similarity); Belongs to the MAL family (182 aa)
            
  0.451
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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