| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CNGA3 | RCVRN | ENSP00000377140 | ENSP00000226193 | Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evok [...] | Recoverin; Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse; EF-hand domain containing | 0.583 |
| CNGA3 | SLC24A2 | ENSP00000377140 | ENSP00000344801 | Cyclic nucleotide-gated cation channel alpha-3; Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of cone photoreceptors. Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGB3 (By similarity). Essential for the generation of light-evok [...] | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers | 0.614 |
| CRKL | HHIP | ENSP00000346300 | ENSP00000296575 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | 0.545 |
| CRKL | KCNIP1 | ENSP00000346300 | ENSP00000414886 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | 0.562 |
| CRKL | SLC24A2 | ENSP00000346300 | ENSP00000344801 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers | 0.560 |
| CRKL | SLC6A1 | ENSP00000346300 | ENSP00000287766 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily | 0.493 |
| CRKL | TRIM4 | ENSP00000346300 | ENSP00000348216 | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | E3 ubiquitin-protein ligase TRIM4; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn’t lead to proteasomal degradation but seems to enhance IFN induction; Belongs to the TRIM/RBCC family | 0.545 |
| GUCA1C | SLC24A2 | ENSP00000261047 | ENSP00000344801 | Guanylyl cyclase-activating protein 3; Stimulates guanylyl cyclase 1 (GC1) and GC2 when free calcium ions concentration is low and inhibits guanylyl cyclases when free calcium ions concentration is elevated. This Ca(2+)- sensitive regulation of guanylyl cyclase (GC) is a key event in recovery of the dark state of rod photoreceptors following light exposure; EF-hand domain containing | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers | 0.618 |
| HHIP | CRKL | ENSP00000296575 | ENSP00000346300 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | 0.545 |
| HHIP | KCNIP1 | ENSP00000296575 | ENSP00000414886 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | 0.636 |
| HHIP | MAP3K4 | ENSP00000296575 | ENSP00000375986 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | Mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6 | 0.514 |
| HHIP | SLC24A2 | ENSP00000296575 | ENSP00000344801 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers | 0.663 |
| HHIP | SLC6A1 | ENSP00000296575 | ENSP00000287766 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily | 0.547 |
| HHIP | TRIM4 | ENSP00000296575 | ENSP00000348216 | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | E3 ubiquitin-protein ligase TRIM4; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn’t lead to proteasomal degradation but seems to enhance IFN induction; Belongs to the TRIM/RBCC family | 0.641 |
| KCNIP1 | CRKL | ENSP00000414886 | ENSP00000346300 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | Crk-like protein; May mediate the transduction of intracellular signals; SH2 domain containing | 0.562 |
| KCNIP1 | HHIP | ENSP00000414886 | ENSP00000296575 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | Hedgehog-interacting protein; Modulates hedgehog signaling in several cell types including brain and lung through direct interaction with members of the hedgehog family | 0.636 |
| KCNIP1 | MAP3K4 | ENSP00000414886 | ENSP00000375986 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | Mitogen-activated protein kinase kinase kinase 4; Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6 | 0.536 |
| KCNIP1 | SLC24A2 | ENSP00000414886 | ENSP00000344801 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | Sodium/potassium/calcium exchanger 2; Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+); Solute carriers | 0.573 |
| KCNIP1 | SLC6A1 | ENSP00000414886 | ENSP00000287766 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | Sodium- and chloride-dependent GABA transporter 1; Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals; Belongs to the sodium-neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily | 0.684 |
| KCNIP1 | TRIM4 | ENSP00000414886 | ENSP00000348216 | Potassium voltage-gated channel interacting protein 1; EF-hand domain containing | E3 ubiquitin-protein ligase TRIM4; E3 ubiquitin-protein ligase. Mediates ’Lys-63’-linked polyubiquitination of the innate immune receptor DDX58, this linkage doesn’t lead to proteasomal degradation but seems to enhance IFN induction; Belongs to the TRIM/RBCC family | 0.608 |
