node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADCK1 | TOX2 | ENSP00000238561 | ENSP00000344724 | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.480 |
BBX | THEMIS | ENSP00000319974 | ENSP00000357231 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family | 0.572 |
BBX | TOX2 | ENSP00000319974 | ENSP00000344724 | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.451 |
BRF2 | TOX2 | ENSP00000220659 | ENSP00000344724 | Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.475 |
IBTK | TOX2 | ENSP00000305721 | ENSP00000344724 | Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription; Ankyrin repeat domain containing | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.451 |
LGALS4 | TOX2 | ENSP00000302100 | ENSP00000344724 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.577 |
LGALS4 | ZNF461 | ENSP00000302100 | ENSP00000467931 | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | Zinc finger protein 461; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.537 |
ST5 | TOX2 | ENSP00000433528 | ENSP00000344724 | Suppression of tumorigenicity 5 protein; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth; DENN/MADD domain containing | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.550 |
STOX1 | TOX2 | ENSP00000298596 | ENSP00000344724 | Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.516 |
THEMIS | BBX | ENSP00000357231 | ENSP00000319974 | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.572 |
THEMIS | TOX | ENSP00000357231 | ENSP00000354842 | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | 0.528 |
THEMIS | TOX2 | ENSP00000357231 | ENSP00000344724 | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.602 |
TOX | THEMIS | ENSP00000354842 | ENSP00000357231 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family | 0.528 |
TOX | TOX2 | ENSP00000354842 | ENSP00000344724 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | 0.708 |
TOX | ZNF461 | ENSP00000354842 | ENSP00000467931 | Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development | Zinc finger protein 461; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family | 0.563 |
TOX2 | ADCK1 | ENSP00000344724 | ENSP00000238561 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) | 0.480 |
TOX2 | BBX | ENSP00000344724 | ENSP00000319974 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase | 0.451 |
TOX2 | BRF2 | ENSP00000344724 | ENSP00000220659 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family | 0.475 |
TOX2 | IBTK | ENSP00000344724 | ENSP00000305721 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription; Ankyrin repeat domain containing | 0.451 |
TOX2 | LGALS4 | ENSP00000344724 | ENSP00000302100 | TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system | Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins | 0.577 |