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  • 11.0 [archived version]
STRINGSTRING
ZNF461 ZNF461 LGALS4 LGALS4 TOX TOX ADCK1 ADCK1 THEMIS THEMIS BBX BBX TOX2 TOX2 ST5 ST5 STOX1 STOX1 IBTK IBTK BRF2 BRF2
"TOX2" - TOX high mobility group box family member 2 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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TOX2TOX high mobility group box family member 2; Putative transcriptional activator involved in the hypothalamo-pituitary-gonadal system (506 aa)    
Predicted Functional Partners:
ZNF461
Zinc finger protein 461; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family (563 aa)
       
 
  0.957
TOX
Thymocyte selection-associated high mobility group box protein TOX; May play a role in regulating T-cell development (526 aa)
       
 
0.708
THEMIS
Protein THEMIS; Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk; Belongs to the themis family (641 aa)
           
  0.602
LGALS4
Galectin-4; Galectin that binds lactose and a related range of sugars. May be involved in the assembly of adherens junctions; Galectins (323 aa)
       
 
  0.577
ST5
Suppression of tumorigenicity 5 protein; Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth; DENN/MADD domain containing (1137 aa)
           
  0.550
STOX1
Storkhead-box protein 1; Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity) (989 aa)
           
  0.516
ADCK1
Uncharacterized aarF domain-containing protein kinase 1; The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (523 aa)
     
   
  0.480
BRF2
Transcription factor IIIB 50 kDa subunit; General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites. Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress. Down-regulates expression of target genes in response to oxidative stress. Overexpression protects cells against apoptosis in response to oxidative stress; Belongs to the TFIIB family (419 aa)
     
 
  0.475
IBTK
Inhibitor of Bruton tyrosine kinase; Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription; Ankyrin repeat domain containing (1353 aa)
     
   
  0.451
BBX
HMG box transcription factor BBX; Transcription factor that is necessary for cell cycle progression from G1 to S phase (941 aa)
     
   
  0.451
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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