node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACACB | BTG3 | ENSP00000341044 | ENSP00000344609 | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | 0.641 |
BTG3 | ACACB | ENSP00000344609 | ENSP00000341044 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Acetyl-CoA carboxylase 2; Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage (By similarity). May play a role in regulation of mitochondrial fatty acid oxidation through malonyl- CoA-dependent inhibition of carnitine palmitoyltransferase 1 (By similarity) | 0.641 |
BTG3 | CHEK1 | ENSP00000344609 | ENSP00000388648 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Serine/threonine-protein kinase Chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and pho [...] | 0.705 |
BTG3 | CNOT11 | ENSP00000344609 | ENSP00000289382 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | 0.808 |
BTG3 | CNOT7 | ENSP00000344609 | ENSP00000355279 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | 0.945 |
BTG3 | CNOT8 | ENSP00000344609 | ENSP00000430493 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | CCR4-NOT transcription complex subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] | 0.712 |
BTG3 | GNG13 | ENSP00000344609 | ENSP00000248150 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction | 0.664 |
BTG3 | NANOS2 | ENSP00000344609 | ENSP00000341021 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Nanos homolog 2; Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for t [...] | 0.687 |
BTG3 | RIBC1 | ENSP00000344609 | ENSP00000364476 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.812 |
BTG3 | TEX13A | ENSP00000344609 | ENSP00000471604 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Testis-expressed protein 13A; Zinc fingers RANBP2-type ; Belongs to the TEX13 family | 0.672 |
BTG3 | YBX2 | ENSP00000344609 | ENSP00000007699 | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | Y-box-binding protein 2; Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full-length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5’-UCCAUCA-3’ with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasm [...] | 0.645 |
CHEK1 | BTG3 | ENSP00000388648 | ENSP00000344609 | Serine/threonine-protein kinase Chk1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and pho [...] | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | 0.705 |
CNOT11 | BTG3 | ENSP00000289382 | ENSP00000344609 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | 0.808 |
CNOT11 | CNOT7 | ENSP00000289382 | ENSP00000355279 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | 0.994 |
CNOT11 | CNOT8 | ENSP00000289382 | ENSP00000430493 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | CCR4-NOT transcription complex subunit 8; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a [...] | 0.994 |
CNOT11 | NANOS2 | ENSP00000289382 | ENSP00000341021 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | Nanos homolog 2; Plays a key role in the sexual differentiation of germ cells by promoting the male fate but suppressing the female fate. Represses the female fate pathways by suppressing meiosis, which in turn results in the promotion of the male fate. Maintains the suppression of meiosis by preventing STRA8 expression, which is required for premeiotic DNA replication, after CYP26B1 is decreased. Regulates the localization of the CCR4-NOT deadenylation complex to P-bodies and plays a role in recruiting the complex to trigger the degradation of mRNAs involved in meiosis. Required for t [...] | 0.873 |
CNOT11 | RIBC1 | ENSP00000289382 | ENSP00000364476 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | RIB43A domain with coiled-coils 1; Belongs to the RIB43A family | 0.826 |
CNOT11 | TEX13A | ENSP00000289382 | ENSP00000471604 | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | Testis-expressed protein 13A; Zinc fingers RANBP2-type ; Belongs to the TEX13 family | 0.821 |
CNOT7 | BTG3 | ENSP00000355279 | ENSP00000344609 | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | Protein BTG3; BTG anti-proliferation factor 3; BTG/Tob family | 0.945 |
CNOT7 | CNOT11 | ENSP00000355279 | ENSP00000289382 | CCR4-NOT transcription complex subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translationa [...] | CCR4-NOT transcription complex subunit 11; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Seems not to be required for complex deadenylase function; Belongs to the CNOT11 family | 0.994 |