• Version:
  • 11.0 [archived version]
STRINGSTRING
RIMBP3B RIMBP3B RIMBP3C RIMBP3C ALS2CR11 ALS2CR11 ROPN1L ROPN1L TSACC TSACC FSCB FSCB AKAP3 AKAP3 CABYR CABYR ROPN1 ROPN1 TMEM190 TMEM190 TCTE1 TCTE1
"FSCB" - Fibrous sheath CABYR-binding protein in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
FSCBFibrous sheath CABYR-binding protein; May be involved in the later stages of fibrous sheath biogenesis and spermatozoa capacitation. Inhibits ROPN1 and ROPN1L SUMOylation. Binds calcium (825 aa)    
Predicted Functional Partners:
CABYR
Calcium-binding tyrosine phosphorylation-regulated protein; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium (493 aa)
       
 
  0.928
TMEM190
Transmembrane protein 190 (177 aa)
     
   
  0.707
ROPN1
Ropporin-1A; Important for male fertility. With ROPN1L, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation; Belongs to the ropporin family (212 aa)
     
   
  0.568
TSACC
TSSK6-activating co-chaperone protein; Co-chaperone that facilitates HSP-mediated activation of TSSK6; Belongs to the TSACC family (125 aa)
           
  0.560
TCTE1
T-complex-associated-testis-expressed 1; Dynein regulatory complex (501 aa)
           
  0.552
ROPN1L
Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation (230 aa)
           
  0.551
RIMBP3C
RIMS binding protein 3C; Belongs to the RIMBP family (1639 aa)
     
   
  0.549
ALS2CR11
C2 calcium-dependent domain-containing protein 6; Amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11 (1820 aa)
     
   
  0.542
AKAP3
A-kinase anchor protein 3; May function as a regulator of both motility- and head- associated functions such as capacitation and the acrosome reaction; A-kinase anchoring proteins (853 aa)
     
 
  0.540
RIMBP3B
RIMS binding protein 3B (1639 aa)
     
   
  0.529
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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