node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTR5 | GTF2H1 | ENSP00000243903 | ENSP00000265963 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair; Belongs to the actin family. ARP5 subfamily | General transcription factor IIH subunit 1; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | 0.415 |
ACTR5 | MED8 | ENSP00000243903 | ENSP00000290663 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair; Belongs to the actin family. ARP5 subfamily | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targe [...] | 0.707 |
ACTR5 | PTAR1 | ENSP00000243903 | ENSP00000344299 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair; Belongs to the actin family. ARP5 subfamily | Protein prenyltransferase alpha subunit repeat containing 1 | 0.498 |
C7orf25 | PTAR1 | ENSP00000413029 | ENSP00000344299 | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family | Protein prenyltransferase alpha subunit repeat containing 1 | 0.475 |
DCP2 | PTAR1 | ENSP00000373715 | ENSP00000344299 | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. Blocks autophagy in nutrient-rich conditions by repressing the expression [...] | Protein prenyltransferase alpha subunit repeat containing 1 | 0.482 |
FNTA | PTAR1 | ENSP00000303423 | ENSP00000344299 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation | Protein prenyltransferase alpha subunit repeat containing 1 | 0.631 |
FNTA | RABGGTB | ENSP00000303423 | ENSP00000317473 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A; Belongs to the protein prenyltransferase subunit beta family | 0.875 |
GTF2H1 | ACTR5 | ENSP00000265963 | ENSP00000243903 | General transcription factor IIH subunit 1; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair; Belongs to the actin family. ARP5 subfamily | 0.415 |
GTF2H1 | PTAR1 | ENSP00000265963 | ENSP00000344299 | General transcription factor IIH subunit 1; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | Protein prenyltransferase alpha subunit repeat containing 1 | 0.477 |
MED8 | ACTR5 | ENSP00000290663 | ENSP00000243903 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targe [...] | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair; Belongs to the actin family. ARP5 subfamily | 0.707 |
MED8 | PTAR1 | ENSP00000290663 | ENSP00000344299 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targe [...] | Protein prenyltransferase alpha subunit repeat containing 1 | 0.588 |
PTAR1 | ACTR5 | ENSP00000344299 | ENSP00000243903 | Protein prenyltransferase alpha subunit repeat containing 1 | Actin-related protein 5; Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair; Belongs to the actin family. ARP5 subfamily | 0.498 |
PTAR1 | C7orf25 | ENSP00000344299 | ENSP00000413029 | Protein prenyltransferase alpha subunit repeat containing 1 | UPF0415 protein C7orf25; Chromosome 7 open reading frame 25; Belongs to the UPF0415 family | 0.475 |
PTAR1 | DCP2 | ENSP00000344299 | ENSP00000373715 | Protein prenyltransferase alpha subunit repeat containing 1 | m7GpppN-mRNA hydrolase; Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5’-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety. Blocks autophagy in nutrient-rich conditions by repressing the expression [...] | 0.482 |
PTAR1 | FNTA | ENSP00000344299 | ENSP00000303423 | Protein prenyltransferase alpha subunit repeat containing 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha; Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation | 0.631 |
PTAR1 | GTF2H1 | ENSP00000344299 | ENSP00000265963 | Protein prenyltransferase alpha subunit repeat containing 1 | General transcription factor IIH subunit 1; Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II; General transcription factors | 0.477 |
PTAR1 | MED8 | ENSP00000344299 | ENSP00000290663 | Protein prenyltransferase alpha subunit repeat containing 1 | Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a targe [...] | 0.588 |
PTAR1 | RABGGTB | ENSP00000344299 | ENSP00000317473 | Protein prenyltransferase alpha subunit repeat containing 1 | Geranylgeranyl transferase type-2 subunit beta; Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A; Belongs to the protein prenyltransferase subunit beta family | 0.705 |
PTAR1 | TAAR1 | ENSP00000344299 | ENSP00000275216 | Protein prenyltransferase alpha subunit repeat containing 1 | Trace amine-associated receptor 1; Receptor for trace amines, including beta- phenylethylamine (b-PEA), p-tyramine (p-TYR), octopamine and tryptamine, with highest affinity for b-PEA and p-TYR. Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin. Trace amines are biogenic amines present in very low levels in mammalian tissues. Although some trace amines have clearly defined roles as neurotransmitters in invertebrates, the extent to which they function as true neurotransmitters in vertebrates has remained sp [...] | 0.624 |
PTAR1 | YIPF5 | ENSP00000344299 | ENSP00000274496 | Protein prenyltransferase alpha subunit repeat containing 1 | Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing | 0.516 |