LRRC43 protein (human) - STRING database

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LRRC43

Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43 (656 aa)

Predicted Functional Partners:

LPHN3

0.683

LPHN1

0.683

LPHN2

0.683

CEP68

0.668

DCAF4

0.642

DCBLD2

0.642

SBF1

0.590

ENPP5

0.545

FILIP1

0.535

PDZD2

0.481

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CEP68	DCAF4	ENSP00000367229	ENSP00000351147	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors	0.473
CEP68	DCBLD2	ENSP00000367229	ENSP00000321573	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	Discoidin, CUB and LCCL domain containing 2	0.556
CEP68	FILIP1	ENSP00000367229	ENSP00000237172	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A	0.514
CEP68	LRRC43	ENSP00000367229	ENSP00000344233	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.668
DCAF4	CEP68	ENSP00000351147	ENSP00000367229	DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	0.473
DCAF4	LRRC43	ENSP00000351147	ENSP00000344233	DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.642
DCBLD2	CEP68	ENSP00000321573	ENSP00000367229	Discoidin, CUB and LCCL domain containing 2	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	0.556
DCBLD2	LRRC43	ENSP00000321573	ENSP00000344233	Discoidin, CUB and LCCL domain containing 2	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.642
ENPP5	LRRC43	ENSP00000360436	ENSP00000344233	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity); Belongs to the nucleotide pyrophosphatase/phosphodiesterase family	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.545
FILIP1	CEP68	ENSP00000237172	ENSP00000367229	Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	0.514
FILIP1	LRRC43	ENSP00000237172	ENSP00000344233	Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.535
LPHN1	LRRC43	ENSP00000340688	ENSP00000344233	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.683
LPHN2	LRRC43	ENSP00000322270	ENSP00000344233	Adhesion G protein-coupled receptor L2; Calcium-independent receptor of low affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor probably implicated in the regulation of exocytosis; Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.683
LPHN3	LRRC43	ENSP00000422533	ENSP00000344233	Adhesion G protein-coupled receptor L3; Plays a role in cell-cell adhesion and neuron guidance via its interactions with FLRT2 and FLRT3 that are expressed at the surface of adjacent cells. Plays a role in the development of glutamatergic synapses in the cortex. Important in determining the connectivity rates between the principal neurons in the cortex; Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	0.683
LRRC43	CEP68	ENSP00000344233	ENSP00000367229	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	Centrosomal protein of 68 kDa; Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting. Required for localization of CDK5RAP2 to the centrosome during interphase	0.668
LRRC43	DCAF4	ENSP00000344233	ENSP00000351147	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	DDB1- and CUL4-associated factor 4; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex; DDB1 and CUL4 associated factors	0.642
LRRC43	DCBLD2	ENSP00000344233	ENSP00000321573	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	Discoidin, CUB and LCCL domain containing 2	0.642
LRRC43	ENPP5	ENSP00000344233	ENSP00000360436	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	Ectonucleotide pyrophosphatase/phosphodiesterase family member 5; May play a role in neuronal cell communication. Lacks nucleotide pyrophosphatase and lysopholipase D activity (By similarity); Belongs to the nucleotide pyrophosphatase/phosphodiesterase family	0.545
LRRC43	FILIP1	ENSP00000344233	ENSP00000237172	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	Filamin-A-interacting protein 1; By acting through a filamin-A/F-actin axis, it controls the start of neocortical cell migration from the ventricular zone. May be able to induce the degradation of filamin-A	0.535
LRRC43	LPHN1	ENSP00000344233	ENSP00000340688	Leucine-rich repeat-containing protein 43; Leucine rich repeat containing 43	Adhesion G protein-coupled receptor L1; Calcium-independent receptor of high affinity for alpha- latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells. Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity)	0.683

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