| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IFNA17 | IFNA2 | ENSP00000411940 | ENSP00000369554 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | 0.905 |
| IFNA17 | IFNAR1 | ENSP00000411940 | ENSP00000270139 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity) | 0.954 |
| IFNA17 | IFNAR2 | ENSP00000411940 | ENSP00000343957 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity | 0.950 |
| IFNA17 | IFNB1 | ENSP00000411940 | ENSP00000369581 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family | 0.916 |
| IFNA17 | IRF9 | ENSP00000411940 | ENSP00000380073 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Interferon regulatory factor 9; Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1-STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state | 0.950 |
| IFNA17 | JAK1 | ENSP00000411940 | ENSP00000343204 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor; FERM domain containing | 0.926 |
| IFNA17 | STAT1 | ENSP00000411940 | ENSP00000354394 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF [...] | 0.505 |
| IFNA17 | STAT2 | ENSP00000411940 | ENSP00000315768 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | 0.947 |
| IFNA17 | TYK2 | ENSP00000411940 | ENSP00000431885 | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | Non-receptor tyrosine-protein kinase TYK2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain; FERM domain containing | 0.928 |
| IFNA2 | IFNA17 | ENSP00000369554 | ENSP00000411940 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.905 |
| IFNA2 | IFNAR1 | ENSP00000369554 | ENSP00000270139 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity) | 0.994 |
| IFNA2 | IFNAR2 | ENSP00000369554 | ENSP00000343957 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity | 0.993 |
| IFNA2 | IFNB1 | ENSP00000369554 | ENSP00000369581 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon beta; Has antiviral, antibacterial and anticancer activities; Belongs to the alpha/beta interferon family | 0.916 |
| IFNA2 | IRF9 | ENSP00000369554 | ENSP00000380073 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Interferon regulatory factor 9; Transcription factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. IRF9/ISGF3G associates with the phosphorylated STAT1-STAT2 dimer to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state | 0.950 |
| IFNA2 | JAK1 | ENSP00000369554 | ENSP00000343204 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Tyrosine-protein kinase JAK1; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor; FERM domain containing | 0.935 |
| IFNA2 | STAT1 | ENSP00000369554 | ENSP00000354394 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Signal transducer and activator of transcription 1-alpha/beta; Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF [...] | 0.540 |
| IFNA2 | STAT2 | ENSP00000369554 | ENSP00000315768 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Signal transducer and activator of transcription 2; Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive [...] | 0.944 |
| IFNA2 | TYK2 | ENSP00000369554 | ENSP00000431885 | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | Non-receptor tyrosine-protein kinase TYK2; Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain; FERM domain containing | 0.929 |
| IFNAR1 | IFNA17 | ENSP00000270139 | ENSP00000411940 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity) | Interferon alpha-17; Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes- a protein kinase and an oligoadenylate synthetase; Interferons | 0.954 |
| IFNAR1 | IFNA2 | ENSP00000270139 | ENSP00000369554 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves. Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity) | Interferon alpha-2; Produced by macrophages, IFN-alpha have antiviral activities; Interferons | 0.994 |
