NLRP13 protein (human) - STRING database

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NLRP13

NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family (1043 aa)

Predicted Functional Partners:

MEFV

0.633

ACCSL

0.599

DEFB112

0.518

OOSP2

0.473

CASP1

0.469

NLRC4

0.462

PATL2

0.461

BMP15

0.434

DMRTC2

0.432

C1orf21

0.426

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACCSL	BMP15	ENSP00000368109	ENSP00000252677	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins	0.428
ACCSL	DEFB112	ENSP00000368109	ENSP00000319126	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	Beta-defensin 112; Has antibacterial activity; Defensins, beta	0.590
ACCSL	DMRTC2	ENSP00000368109	ENSP00000269945	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family	0.529
ACCSL	NLRP13	ENSP00000368109	ENSP00000343891	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family	0.599
ACCSL	PATL2	ENSP00000368109	ENSP00000416673	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	Protein PAT1 homolog 2; RNA-binding protein that acts as a translational repressor; Armadillo-like helical domain containing	0.558
BMP15	ACCSL	ENSP00000252677	ENSP00000368109	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	0.428
BMP15	NLRP13	ENSP00000252677	ENSP00000343891	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins	NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family	0.434
BMP15	OOSP2	ENSP00000252677	ENSP00000278855	Bone morphogenetic protein 15; May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth; Bone morphogenetic proteins	Oocyte secreted protein 2	0.567
C1orf21	NLRP13	ENSP00000235307	ENSP00000343891	Uncharacterized protein C1orf21; Chromosome 1 open reading frame 21	NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family	0.426
CASP1	MEFV	ENSP00000433138	ENSP00000219596	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	Pyrin; Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma. Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy. Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18- mediated inflammation. However, i [...]	0.967
CASP1	NLRC4	ENSP00000433138	ENSP00000385090	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	NLR family CARD domain-containing protein 4; Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis; Caspase recruitment domain containing	0.997
CASP1	NLRP13	ENSP00000433138	ENSP00000343891	Caspase-1; Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive; Belongs to the peptidase C14A family	NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family	0.469
DEFB112	ACCSL	ENSP00000319126	ENSP00000368109	Beta-defensin 112; Has antibacterial activity; Defensins, beta	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	0.590
DEFB112	DMRTC2	ENSP00000319126	ENSP00000269945	Beta-defensin 112; Has antibacterial activity; Defensins, beta	Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family	0.527
DEFB112	NLRP13	ENSP00000319126	ENSP00000343891	Beta-defensin 112; Has antibacterial activity; Defensins, beta	NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family	0.518
DEFB112	PATL2	ENSP00000319126	ENSP00000416673	Beta-defensin 112; Has antibacterial activity; Defensins, beta	Protein PAT1 homolog 2; RNA-binding protein that acts as a translational repressor; Armadillo-like helical domain containing	0.559
DMRTC2	ACCSL	ENSP00000269945	ENSP00000368109	Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family	Probable inactive 1-aminocyclopropane-1-carboxylate synthase-like protein 2; 1-aminocyclopropane-1-carboxylate synthase homolog like; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family	0.529
DMRTC2	DEFB112	ENSP00000269945	ENSP00000319126	Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family	Beta-defensin 112; Has antibacterial activity; Defensins, beta	0.527
DMRTC2	NLRP13	ENSP00000269945	ENSP00000343891	Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family	NACHT, LRR and PYD domains-containing protein 13; Involved in inflammation; NLR family	0.432
DMRTC2	PATL2	ENSP00000269945	ENSP00000416673	Doublesex- and mab-3-related transcription factor C2; May be involved in sexual development; Belongs to the DMRT family	Protein PAT1 homolog 2; RNA-binding protein that acts as a translational repressor; Armadillo-like helical domain containing	0.512

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