| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACER1 | CERK | ENSP00000301452 | ENSP00000216264 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides | 0.963 |
| ACER1 | CKAP4 | ENSP00000301452 | ENSP00000367265 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | 0.499 |
| ACER1 | CPTP | ENSP00000301452 | ENSP00000343890 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.547 |
| ACER1 | LOC646862 | ENSP00000301452 | ENSP00000470441 | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | RING finger protein 225; Uncharacterized protein LOC646862 | 0.451 |
| ACPT | CPTP | ENSP00000270593 | ENSP00000343890 | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.708 |
| CERK | ACER1 | ENSP00000216264 | ENSP00000301452 | Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | 0.963 |
| CERK | CPTP | ENSP00000216264 | ENSP00000343890 | Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.643 |
| CKAP4 | ACER1 | ENSP00000367265 | ENSP00000301452 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | 0.499 |
| CKAP4 | CPTP | ENSP00000367265 | ENSP00000343890 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | 0.494 |
| CKAP4 | LOC646862 | ENSP00000367265 | ENSP00000470441 | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | RING finger protein 225; Uncharacterized protein LOC646862 | 0.457 |
| CPTP | ACER1 | ENSP00000343890 | ENSP00000301452 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Alkaline ceramidase 1; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids (By similarity); Alkaline ceramidases | 0.547 |
| CPTP | ACPT | ENSP00000343890 | ENSP00000270593 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Testicular acid phosphatase; May dephosphorylate receptor tyrosine-protein kinase ERBB4 and inhibits its ligand-induced proteolytic cleavage. May play a role in odontogenesis | 0.708 |
| CPTP | CERK | ENSP00000343890 | ENSP00000216264 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Ceramide kinase; Catalyzes specifically the phosphorylation of ceramide to form ceramide 1-phosphate. Acts efficiently on natural and analog ceramides (C6, C8, C16 ceramides, and C8-dihydroceramide), to a lesser extent on C2-ceramide and C6-dihydroceramide, but not on other lipids, such as various sphingosines. Binds phosphoinositides | 0.643 |
| CPTP | CKAP4 | ENSP00000343890 | ENSP00000367265 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Cytoskeleton-associated protein 4; High-affinity epithelial cell surface receptor for APF | 0.494 |
| CPTP | DFFB | ENSP00000343890 | ENSP00000339524 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | DNA fragmentation factor subunit beta; Nuclease that induces DNA fragmentation and chromatin condensation during apoptosis. Degrades naked DNA and induces apoptotic morphology | 0.475 |
| CPTP | GLTP | ENSP00000343890 | ENSP00000315263 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Glycolipid transfer protein; Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides | 0.619 |
| CPTP | LOC646862 | ENSP00000343890 | ENSP00000470441 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | RING finger protein 225; Uncharacterized protein LOC646862 | 0.453 |
| CPTP | PIK3IP1 | ENSP00000343890 | ENSP00000215912 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Phosphoinositide-3-kinase-interacting protein 1; Negative regulator of hepatic phosphatidylinositol 3- kinase (PI3K) activity | 0.459 |
| CPTP | RERE | ENSP00000343890 | ENSP00000338629 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Arginine-glutamic acid dipeptide repeats protein; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death; GATA zinc finger domain containing | 0.458 |
| CPTP | WBSCR27 | ENSP00000343890 | ENSP00000297873 | Ceramide-1-phosphate transfer protein; Mediates the intracellular transfer of ceramide-1- phosphate between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16-0 or monounsaturated C18-1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24-0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and t [...] | Methyltransferase-like protein 27; Williams Beuren syndrome chromosome region 27 | 0.464 |
