| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHN2 | CLCA4 | ENSP00000222792 | ENSP00000359594 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | 0.409 |
| CHN2 | CPNE4 | ENSP00000222792 | ENSP00000478878 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | 0.521 |
| CHN2 | EDIL3 | ENSP00000222792 | ENSP00000296591 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | 0.418 |
| CHN2 | FRMD4B | ENSP00000222792 | ENSP00000381549 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | 0.578 |
| CHN2 | GFRA2 | ENSP00000222792 | ENSP00000428518 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor | 0.423 |
| CHN2 | TMCC3 | ENSP00000222792 | ENSP00000261226 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | Transmembrane and coiled-coil domain containing; Belongs to the TEX28 family | 0.513 |
| CHN2 | TMTC4 | ENSP00000222792 | ENSP00000343871 | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family | 0.627 |
| CLCA4 | CHN2 | ENSP00000359594 | ENSP00000222792 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | 0.409 |
| CLCA4 | EDIL3 | ENSP00000359594 | ENSP00000296591 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | 0.564 |
| CLCA4 | TMCC3 | ENSP00000359594 | ENSP00000261226 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | Transmembrane and coiled-coil domain containing; Belongs to the TEX28 family | 0.625 |
| CLCA4 | TMTC4 | ENSP00000359594 | ENSP00000343871 | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family | 0.606 |
| CPNE4 | CHN2 | ENSP00000478878 | ENSP00000222792 | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | 0.521 |
| CPNE4 | FRMD4B | ENSP00000478878 | ENSP00000381549 | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | FERM domain-containing protein 4B; Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization; FERM domain containing | 0.717 |
| CPNE4 | GFRA2 | ENSP00000478878 | ENSP00000428518 | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor | 0.610 |
| CPNE4 | TMTC4 | ENSP00000478878 | ENSP00000343871 | Copine-4; Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes; Belongs to the copine family | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family | 0.782 |
| EDIL3 | CHN2 | ENSP00000296591 | ENSP00000222792 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | Beta-chimaerin; GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors | 0.418 |
| EDIL3 | CLCA4 | ENSP00000296591 | ENSP00000359594 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | Calcium-activated chloride channel regulator 4; May be involved in mediating calcium-activated chloride conductance; Chloride channel accessory | 0.564 |
| EDIL3 | TMCC3 | ENSP00000296591 | ENSP00000261226 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | Transmembrane and coiled-coil domain containing; Belongs to the TEX28 family | 0.623 |
| EDIL3 | TMTC4 | ENSP00000296591 | ENSP00000343871 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | Transmembrane and tetratricopeptide repeat containing 4; Belongs to the TMTC family | 0.614 |
| EDIL3 | UNC79 | ENSP00000296591 | ENSP00000256339 | EGF-like repeat and discoidin I-like domain-containing protein 3; Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development | Protein unc-79 homolog; Component of the NALCN sodium channel complex, a cation channel activated either by neuropeptides substance P or neurotensin that controls neuronal excitability; Belongs to the unc-79 family | 0.519 |
