node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C18orf21 | GFRAL | ENSP00000465517 | ENSP00000343636 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | GDNF family receptor alpha like | 0.517 |
C18orf21 | NABP2 | ENSP00000465517 | ENSP00000369545 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.637 |
C18orf21 | RPRD1A | ENSP00000465517 | ENSP00000381984 | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | Regulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle | 0.743 |
GAS1 | GFRAL | ENSP00000298743 | ENSP00000343636 | Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells | GDNF family receptor alpha like | 0.690 |
GDF15 | GFRAL | ENSP00000252809 | ENSP00000343636 | Growth differentiation factor 15; Belongs to the TGF-beta family | GDNF family receptor alpha like | 0.929 |
GDNF | GFRAL | ENSP00000409007 | ENSP00000343636 | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake; Belongs to the TGF-beta family. GDNF subfamily | GDNF family receptor alpha like | 0.581 |
GDNF | NRTN | ENSP00000409007 | ENSP00000302648 | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake; Belongs to the TGF-beta family. GDNF subfamily | Neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells; Belongs to the TGF-beta family. GDNF subfamily | 0.918 |
GDNF | PSPN | ENSP00000409007 | ENSP00000245810 | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake; Belongs to the TGF-beta family. GDNF subfamily | Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons; GDNF family ligands | 0.918 |
GFRAL | C18orf21 | ENSP00000343636 | ENSP00000465517 | GDNF family receptor alpha like | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | 0.517 |
GFRAL | GAS1 | ENSP00000343636 | ENSP00000298743 | GDNF family receptor alpha like | Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells | 0.690 |
GFRAL | GDF15 | ENSP00000343636 | ENSP00000252809 | GDNF family receptor alpha like | Growth differentiation factor 15; Belongs to the TGF-beta family | 0.929 |
GFRAL | GDNF | ENSP00000343636 | ENSP00000409007 | GDNF family receptor alpha like | Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake; Belongs to the TGF-beta family. GDNF subfamily | 0.581 |
GFRAL | NABP2 | ENSP00000343636 | ENSP00000369545 | GDNF family receptor alpha like | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | 0.430 |
GFRAL | NRTN | ENSP00000343636 | ENSP00000302648 | GDNF family receptor alpha like | Neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells; Belongs to the TGF-beta family. GDNF subfamily | 0.676 |
GFRAL | OR51Q1 | ENSP00000343636 | ENSP00000300778 | GDNF family receptor alpha like | Olfactory receptor 51Q1; Odorant receptor; Olfactory receptors, family 51 | 0.530 |
GFRAL | PSPN | ENSP00000343636 | ENSP00000245810 | GDNF family receptor alpha like | Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons; GDNF family ligands | 0.681 |
GFRAL | RPRD1A | ENSP00000343636 | ENSP00000381984 | GDNF family receptor alpha like | Regulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle | 0.459 |
GFRAL | SARM1 | ENSP00000343636 | ENSP00000468032 | GDNF family receptor alpha like | Sterile alpha and TIR motif-containing protein 1; Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent ac [...] | 0.585 |
NABP2 | C18orf21 | ENSP00000369545 | ENSP00000465517 | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 | 0.637 |
NABP2 | GFRAL | ENSP00000369545 | ENSP00000343636 | SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] | GDNF family receptor alpha like | 0.430 |