• Version:
  • 11.0 [archived version]
STRINGSTRING
NABP2 NABP2 RPRD1A RPRD1A C18orf21 C18orf21 GDNF GDNF NRTN NRTN SARM1 SARM1 PSPN PSPN GFRAL GFRAL GAS1 GAS1 OR51Q1 OR51Q1 GDF15 GDF15
"GFRAL" - GDNF family receptor alpha like in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GFRALGDNF family receptor alpha like (394 aa)    
Predicted Functional Partners:
GDF15
Growth differentiation factor 15; Belongs to the TGF-beta family (308 aa)
       
 
  0.929
GAS1
Growth arrest-specific protein 1; Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells (345 aa)
           
  0.690
PSPN
Persephin; Exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons; GDNF family ligands (156 aa)
       
 
  0.681
NRTN
Neurturin; Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells; Belongs to the TGF-beta family. GDNF subfamily (197 aa)
       
 
  0.676
SARM1
Sterile alpha and TIR motif-containing protein 1; Negative regulator of MYD88- and TRIF-dependent toll- like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88- dependent activation of JUN/AP-1, TRIF-dependent ac [...] (724 aa)
           
  0.585
GDNF
Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake; Belongs to the TGF-beta family. GDNF subfamily (228 aa)
       
 
  0.581
OR51Q1
Olfactory receptor 51Q1; Odorant receptor; Olfactory receptors, family 51 (317 aa)
           
  0.530
C18orf21
UPF0711 protein C18orf21; Chromosome 18 open reading frame 21 (220 aa)
           
  0.517
RPRD1A
Regulation of nuclear pre-mRNA domain-containing protein 1A; Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle (312 aa)
           
  0.459
NABP2
SOSS complex subunit B1; Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-s [...] (211 aa)
           
  0.430
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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