node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ETS1 | FOXN2 | ENSP00000376436 | ENSP00000343633 | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.684 |
FOXN2 | ETS1 | ENSP00000343633 | ENSP00000376436 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Protein C-ets-1; Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion | 0.684 |
FOXN2 | GLI3 | ENSP00000343633 | ENSP00000379258 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Transcriptional activator GLI3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in reg [...] | 0.649 |
FOXN2 | HLTF | ENSP00000343633 | ENSP00000308944 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for ’Lys-63’-linked polyubiquitination of chromatin-bound PC [...] | 0.639 |
FOXN2 | HOXC13 | ENSP00000343633 | ENSP00000243056 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity); Belongs to the Abd-B homeobox family | 0.628 |
FOXN2 | KDM3A | ENSP00000343633 | ENSP00000386660 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | 0.518 |
FOXN2 | MBTD1 | ENSP00000343633 | ENSP00000468304 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | 0.514 |
FOXN2 | PIP4K2A | ENSP00000343633 | ENSP00000365757 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels o [...] | 0.585 |
FOXN2 | POLR3A | ENSP00000343633 | ENSP00000361446 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to prom [...] | 0.665 |
FOXN2 | SFTA3 | ENSP00000343633 | ENSP00000428331 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | Surfactant-associated protein 3; Surfactant associated 3 | 0.539 |
FOXN2 | SHPRH | ENSP00000343633 | ENSP00000356475 | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to ’Lys-164’ of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through ’Lys-63’; Belongs to the SNF2/RAD54 helicase family | 0.731 |
GLI3 | FOXN2 | ENSP00000379258 | ENSP00000343633 | Transcriptional activator GLI3; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in reg [...] | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.649 |
HLTF | FOXN2 | ENSP00000308944 | ENSP00000343633 | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for ’Lys-63’-linked polyubiquitination of chromatin-bound PC [...] | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.639 |
HLTF | SHPRH | ENSP00000308944 | ENSP00000356475 | Helicase-like transcription factor; Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for ’Lys-63’-linked polyubiquitination of chromatin-bound PC [...] | E3 ubiquitin-protein ligase SHPRH; E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to ’Lys-164’ of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through ’Lys-63’; Belongs to the SNF2/RAD54 helicase family | 0.673 |
HOXC13 | FOXN2 | ENSP00000243056 | ENSP00000343633 | Homeobox protein Hox-C13; Transcription factor which plays a role in hair follicle differentiation. Regulates FOXQ1 expression and that of other hair-specific genes (By similarity); Belongs to the Abd-B homeobox family | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.628 |
KDM3A | FOXN2 | ENSP00000386660 | ENSP00000343633 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.518 |
KDM3A | POLR3A | ENSP00000386660 | ENSP00000361446 | Lysine-specific demethylase 3A; Histone demethylase that specifically demethylates ’Lys- 9’ of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 ’Lys-9’ residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 ’Lys-9’. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 ’Lys-9’ demethylation and transcriptional activation [...] | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to prom [...] | 0.640 |
MBTD1 | FOXN2 | ENSP00000468304 | ENSP00000343633 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.514 |
PIP4K2A | FOXN2 | ENSP00000365757 | ENSP00000343633 | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels o [...] | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.585 |
POLR3A | FOXN2 | ENSP00000361446 | ENSP00000343633 | DNA-directed RNA polymerase III subunit RPC1; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to prom [...] | Forkhead box protein N2; Binds to the purine-rich region in HTLV-I LTR; Forkhead boxes | 0.665 |