node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
DERL1 | ESYT1 | ENSP00000259512 | ENSP00000267113 | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for prot [...] | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | 0.873 |
DERL1 | YIF1B | ENSP00000259512 | ENSP00000343435 | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for prot [...] | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.865 |
DUPD1 | YIF1B | ENSP00000340609 | ENSP00000343435 | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.674 |
DUPD1 | YIPF7 | ENSP00000340609 | ENSP00000332772 | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family | 0.537 |
DUSP27 | YIF1B | ENSP00000354483 | ENSP00000343435 | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.740 |
ESYT1 | DERL1 | ENSP00000267113 | ENSP00000259512 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for prot [...] | 0.873 |
ESYT1 | YIF1B | ENSP00000267113 | ENSP00000343435 | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.889 |
FAM134C | YIF1B | ENSP00000309432 | ENSP00000343435 | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.642 |
HTR1A | YIF1B | ENSP00000316244 | ENSP00000343435 | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.654 |
IER3IP1 | YIF1B | ENSP00000256433 | ENSP00000343435 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 0.607 |
IER3IP1 | YIPF5 | ENSP00000256433 | ENSP00000274496 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) | Protein YIPF5; Plays a role in transport between endoplasmic reticulum and Golgi; Yip1 domain containing | 0.694 |
IER3IP1 | YIPF6 | ENSP00000256433 | ENSP00000417573 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) | Protein YIPF6; May be required for stable YIPF1 and YIPF2 protein expression; Yip1 domain containing | 0.806 |
IER3IP1 | YIPF7 | ENSP00000256433 | ENSP00000332772 | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) | Protein YIPF7; Yip1 domain family member 7; Belongs to the YIP1 family | 0.634 |
YIF1B | DERL1 | ENSP00000343435 | ENSP00000259512 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | Derlin-1; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for prot [...] | 0.865 |
YIF1B | DUPD1 | ENSP00000343435 | ENSP00000340609 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate | 0.674 |
YIF1B | DUSP27 | ENSP00000343435 | ENSP00000354483 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | Inactive dual specificity phosphatase 27; May be required for myofiber maturation | 0.740 |
YIF1B | ESYT1 | ENSP00000343435 | ENSP00000267113 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | Extended synaptotagmin-1; Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane; Belongs to the extended synaptotagmin family | 0.889 |
YIF1B | FAM134C | ENSP00000343435 | ENSP00000309432 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | Reticulophagy regulator 3; Mediates NRF1-enhanced neurite outgrowth; Belongs to the RETREG family | 0.642 |
YIF1B | HTR1A | ENSP00000343435 | ENSP00000316244 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | 5-hydroxytryptamine receptor 1A; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second [...] | 0.654 |
YIF1B | IER3IP1 | ENSP00000343435 | ENSP00000256433 | Protein YIF1B; Yip1 interacting factor homolog B, membrane trafficking protein; Belongs to the YIF1 family | Immediate early response 3-interacting protein 1; May be implicated in the regulation of apoptosis. May be involved in protein transport between endoplasmic reticulum and Golgi apparatus (By similarity) | 0.607 |