• Version:
  • 11.0 [archived version]
STRINGSTRING
DGCR14 DGCR14 NPR1 NPR1 NPR2 NPR2 SDK2 SDK2 NPPB NPPB NPPC NPPC VMAC VMAC NPR3 NPR3 SMR3A SMR3A C8orf37 C8orf37 ZNF577 ZNF577
"VMAC" - Vimentin type intermediate filament associated coiled-coil protein in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
VMACVimentin type intermediate filament associated coiled-coil protein (169 aa)    
Predicted Functional Partners:
DGCR14
Protein DGCR14; May be involved in pre-mRNA splicing (476 aa)
           
  0.586
SMR3A
Submaxillary gland androgen-regulated protein 3A; May play a role in protection or detoxification (134 aa)
       
      0.537
C8orf37
Protein C8orf37; Chromosome 8 open reading frame 37; Bardet-Biedl syndrome associated (207 aa)
           
  0.529
SDK2
Protein sidekick-2; Adhesion molecule that promotes lamina-specific synaptic connections in the retina and is specifically required for the formation of neuronal circuits that detect motion. Acts by promoting formation of synapses between two specific retinal cell types- the retinal ganglion cells W3B-RGCs and the excitatory amacrine cells VG3-ACs. Formation of synapses between these two cells plays a key role in detection of motion. Promotes synaptic connectivity via homophilic interactions; Fibronectin type III domain containing (2172 aa)
       
      0.513
NPPC
C-type natriuretic peptide; Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity); Endogenous ligands (126 aa)
           
  0.498
NPR3
Atrial natriuretic peptide receptor 3; Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity; DENN/MADD domain containing (541 aa)
           
  0.492
NPR1
Atrial natriuretic peptide receptor 1; Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand (1061 aa)
     
   
  0.492
NPR2
Atrial natriuretic peptide receptor 2; Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth; DENN/MADD domain containing (1047 aa)
           
  0.481
NPPB
Natriuretic peptides B; Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3; Belongs to the natriuretic peptide family (134 aa)
           
  0.474
ZNF577
Zinc finger protein 577; May be involved in transcriptional regulation; Zinc fingers C2H2-type (485 aa)
           
  0.426
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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