node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APOBR | SBK1 | ENSP00000457539 | ENSP00000343248 | Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in mac [...] | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.483 |
GNPTG | NLRC3 | ENSP00000204679 | ENSP00000352039 | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors; MRH domain containing | NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA-dT), but not poly(I-C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating ’Lys-63’- linked ubiquitination and leaving unchanged the degradative ’Lys- 48’-l [...] | 0.508 |
GNPTG | RHOT2 | ENSP00000204679 | ENSP00000321971 | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors; MRH domain containing | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) | 0.517 |
GNPTG | SBK1 | ENSP00000204679 | ENSP00000343248 | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors; MRH domain containing | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.615 |
INVS | SBK1 | ENSP00000262457 | ENSP00000343248 | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be str [...] | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.625 |
IRGQ | SBK1 | ENSP00000387535 | ENSP00000343248 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.483 |
IRGQ | TTC9B | ENSP00000387535 | ENSP00000311760 | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | Tetratricopeptide repeat domain containing | 0.584 |
NLRC3 | GNPTG | ENSP00000352039 | ENSP00000204679 | NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA-dT), but not poly(I-C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating ’Lys-63’- linked ubiquitination and leaving unchanged the degradative ’Lys- 48’-l [...] | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors; MRH domain containing | 0.508 |
NLRC3 | SBK1 | ENSP00000352039 | ENSP00000343248 | NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA-dT), but not poly(I-C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating ’Lys-63’- linked ubiquitination and leaving unchanged the degradative ’Lys- 48’-l [...] | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.527 |
PHF21B | SBK1 | ENSP00000324403 | ENSP00000343248 | PHD finger protein 21B | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.501 |
RHOT2 | GNPTG | ENSP00000321971 | ENSP00000204679 | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors; MRH domain containing | 0.517 |
RHOT2 | SBK1 | ENSP00000321971 | ENSP00000343248 | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | 0.561 |
SBK1 | APOBR | ENSP00000343248 | ENSP00000457539 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | Apolipoprotein B receptor; Macrophage receptor that binds to the apolipoprotein B48 (APOB) of dietary triglyceride (TG)-rich lipoproteins (TRL) or to a like domain of APOB in hypertriglyceridemic very low density lipoprotein (HTG-VLDL). Binds and internalizes TRL when out of the context of the macrophage. May provide essential lipids to reticuloendothelial cells. Could also be involved in foam cell formation with elevated TRL and remnant lipoprotein (RLP). Mediates the rapid high-affinity uptake of chylomicrons (CM), HTG- VLDL, and trypsinized (tryp) VLDL devoid of APOE in vitro in mac [...] | 0.483 |
SBK1 | GNPTG | ENSP00000343248 | ENSP00000204679 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors; MRH domain containing | 0.615 |
SBK1 | INVS | ENSP00000343248 | ENSP00000262457 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | Inversin; Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be str [...] | 0.625 |
SBK1 | IRGQ | ENSP00000343248 | ENSP00000387535 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | Immunity-related GTPase family Q protein; Immunity related GTPase Q; Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family | 0.483 |
SBK1 | NLRC3 | ENSP00000343248 | ENSP00000352039 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | NLR family CARD domain-containing protein 3; Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA-dT), but not poly(I-C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating ’Lys-63’- linked ubiquitination and leaving unchanged the degradative ’Lys- 48’-l [...] | 0.527 |
SBK1 | PHF21B | ENSP00000343248 | ENSP00000324403 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | PHD finger protein 21B | 0.501 |
SBK1 | RHOT2 | ENSP00000343248 | ENSP00000321971 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | Mitochondrial Rho GTPase 2; Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (By similarity) | 0.561 |
SBK1 | STYK1 | ENSP00000343248 | ENSP00000075503 | Serine/threonine-protein kinase SBK1; May be involved in signal-transduction pathways related to the control of brain development | Tyrosine-protein kinase STYK1; Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3’-kinases (PI3K) pathways (By similarity) | 0.647 |