| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CPXCR1 | DUSP21 | ENSP00000276127 | ENSP00000343244 | CPX chromosome region, candidate 1 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.574 |
| CPXCR1 | OR10H5 | ENSP00000276127 | ENSP00000310704 | CPX chromosome region, candidate 1 | Olfactory receptor 10H5; Odorant receptor; Olfactory receptors, family 10 | 0.582 |
| CPXCR1 | PAGE2B | ENSP00000276127 | ENSP00000364110 | CPX chromosome region, candidate 1 | PAGE family member 2B; Belongs to the GAGE family | 0.581 |
| CRYZL1 | DUSP21 | ENSP00000370966 | ENSP00000343244 | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.539 |
| DUSP11 | DUSP21 | ENSP00000272444 | ENSP00000343244 | RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5’-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.595 |
| DUSP21 | CPXCR1 | ENSP00000343244 | ENSP00000276127 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | CPX chromosome region, candidate 1 | 0.574 |
| DUSP21 | CRYZL1 | ENSP00000343244 | ENSP00000370966 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Quinone oxidoreductase-like protein 1; Crystallin zeta like 1; Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily | 0.539 |
| DUSP21 | DUSP11 | ENSP00000343244 | ENSP00000272444 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | RNA/RNP complex-1-interacting phosphatase; Possesses RNA 5’-triphosphatase and diphosphatase activities, but displays a poor protein-tyrosine phosphatase activity. In addition, has phosphatase activity with ATP, ADP and O-methylfluorescein phosphate (in vitro). Binds to RNA. May participate in nuclear mRNA metabolism; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.595 |
| DUSP21 | MAGEA11 | ENSP00000343244 | ENSP00000347358 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | 0.486 |
| DUSP21 | MAGED2 | ENSP00000343244 | ENSP00000364209 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Melanoma-associated antigen D2; Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule; MAGE family | 0.507 |
| DUSP21 | MAPK14 | ENSP00000343244 | ENSP00000229795 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | 0.510 |
| DUSP21 | MUM1L1 | ENSP00000343244 | ENSP00000338641 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | PWWP domain-containing protein MUM1L1; PWWP domain containing; Belongs to the MUM1 family | 0.543 |
| DUSP21 | OR10H5 | ENSP00000343244 | ENSP00000310704 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | Olfactory receptor 10H5; Odorant receptor; Olfactory receptors, family 10 | 0.568 |
| DUSP21 | PAGE2B | ENSP00000343244 | ENSP00000364110 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | PAGE family member 2B; Belongs to the GAGE family | 0.491 |
| DUSP21 | XAGE5 | ENSP00000343244 | ENSP00000342240 | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | X antigen family member 5; Belongs to the GAGE family | 0.510 |
| MAGEA11 | DUSP21 | ENSP00000347358 | ENSP00000343244 | Melanoma-associated antigen 11; Acts as androgen receptor coregulator that increases androgen receptor activity by modulating the receptors interdomain interaction. May play a role in embryonal development and tumor transformation or aspects of tumor progression; MAGE family | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.486 |
| MAGED2 | DUSP21 | ENSP00000364209 | ENSP00000343244 | Melanoma-associated antigen D2; Regulates the expression, localization to the plasma membrane and function of the sodium chloride cotransporters SLC12A1 and SLC12A3, two key components of salt reabsorption in the distal renal tubule; MAGE family | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.507 |
| MAPK14 | DUSP21 | ENSP00000229795 | ENSP00000343244 | Mitogen-activated protein kinase 14; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases which are a [...] | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.510 |
| MUM1L1 | DUSP21 | ENSP00000338641 | ENSP00000343244 | PWWP domain-containing protein MUM1L1; PWWP domain containing; Belongs to the MUM1 family | Dual specificity protein phosphatase 21; Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine; Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily | 0.543 |
| MUM1L1 | PAGE2B | ENSP00000338641 | ENSP00000364110 | PWWP domain-containing protein MUM1L1; PWWP domain containing; Belongs to the MUM1 family | PAGE family member 2B; Belongs to the GAGE family | 0.491 |
