| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CGA | GHRHR | ENSP00000482232 | ENSP00000320180 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | 0.960 |
| CGA | HESX1 | ENSP00000482232 | ENSP00000295934 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5’-AGCTTGAGTCTAATTGAATTAACTGTAC-3’. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation; Belongs to the ANF homeobox family | 0.447 |
| CGA | LHX3 | ENSP00000482232 | ENSP00000360811 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1; LIM class homeoboxes | 0.774 |
| CGA | LHX4 | ENSP00000482232 | ENSP00000263726 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | 0.578 |
| CGA | POU1F1 | ENSP00000482232 | ENSP00000342931 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5’-TAAAT-3’. Activates growth hormone and prolactin genes; Belongs to the POU transcription factor family. Class- 1 subfamily | 0.817 |
| CGA | PRL | ENSP00000482232 | ENSP00000302150 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Prolactin; Prolactin acts primarily on the mammary gland by promoting lactation; Growth hormone family | 0.669 |
| CGA | PROP1 | ENSP00000482232 | ENSP00000311290 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Homeobox protein prophet of Pit-1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes; PRD class homeoboxes and pseudogenes | 0.461 |
| CGA | TBX19 | ENSP00000482232 | ENSP00000356795 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | T-box transcription factor TBX19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters; T-boxes | 0.645 |
| CGA | TSHB | ENSP00000482232 | ENSP00000256592 | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism; Endogenous ligands | 0.988 |
| ESX1 | GHRHR | ENSP00000361669 | ENSP00000320180 | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | 0.577 |
| ESX1 | LHX3 | ENSP00000361669 | ENSP00000360811 | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1; LIM class homeoboxes | 0.786 |
| ESX1 | LHX4 | ENSP00000361669 | ENSP00000263726 | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | 0.863 |
| ESX1 | POU1F1 | ENSP00000361669 | ENSP00000342931 | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes | Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5’-TAAAT-3’. Activates growth hormone and prolactin genes; Belongs to the POU transcription factor family. Class- 1 subfamily | 0.804 |
| ESX1 | TBX19 | ENSP00000361669 | ENSP00000356795 | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes | T-box transcription factor TBX19; Transcriptional regulator involved in developmental processes. Can activate POMC gene expression and repress the alpha glycoprotein subunit and thyroid-stimulating hormone beta promoters; T-boxes | 0.615 |
| GHRHR | CGA | ENSP00000320180 | ENSP00000482232 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | Glycoprotein hormones, alpha polypeptide; Belongs to the glycoprotein hormones subunit alpha family | 0.960 |
| GHRHR | ESX1 | ENSP00000320180 | ENSP00000361669 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | Homeobox protein ESX1; May coordinately regulate cell cycle progression and transcription during spermatogenesis. Inhibits degradation of polyubiquitinated cyclin A and cyclin B1 and thereby arrests the cell cycle at early M phase. ESXR1-N acts as a transcriptional repressor. Binds to the sequence 5’-TAATGTTATTA-3’ which is present within the first intron of the KRAS gene and inhibits its expression. ESXR1-C has the ability to inhibit cyclin turnover; PRD class homeoboxes and pseudogenes | 0.577 |
| GHRHR | HESX1 | ENSP00000320180 | ENSP00000295934 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | Homeobox expressed in ES cells 1; Required for the normal development of the forebrain, eyes and other anterior structures such as the olfactory placodes and pituitary gland. Possible transcriptional repressor. Binds to the palindromic PIII sequence, 5’-AGCTTGAGTCTAATTGAATTAACTGTAC-3’. HESX1 and PROP1 bind as heterodimers on this palindromic site, and, in vitro, HESX1 can antagonize PROP1 activation; Belongs to the ANF homeobox family | 0.648 |
| GHRHR | LHX3 | ENSP00000320180 | ENSP00000360811 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | LIM/homeobox protein Lhx3; Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1; LIM class homeoboxes | 0.774 |
| GHRHR | LHX4 | ENSP00000320180 | ENSP00000263726 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | LIM/homeobox protein Lhx4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung; LIM class homeoboxes | 0.781 |
| GHRHR | POU1F1 | ENSP00000320180 | ENSP00000342931 | Growth hormone-releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion; Belongs to the G-protein coupled receptor 2 family | Pituitary-specific positive transcription factor 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Specifically binds to the consensus sequence 5’-TAAAT-3’. Activates growth hormone and prolactin genes; Belongs to the POU transcription factor family. Class- 1 subfamily | 0.848 |
