node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ENSG00000274933 | ZNF669 | ENSP00000481258 | ENSP00000342818 | TBC1 domain family member 3I; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.413 |
RBM19 | ZNF669 | ENSP00000442053 | ENSP00000342818 | Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development; RNA binding motif containing | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.441 |
TADA2A | TBC1D3G | ENSP00000481091 | ENSP00000456861 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.499 |
TADA2A | TBC1D3H | ENSP00000481091 | ENSP00000482630 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.537 |
TADA2A | ZNF669 | ENSP00000481091 | ENSP00000342818 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.443 |
TADA2A | ZNHIT3 | ENSP00000481091 | ENSP00000484687 | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | Zinc finger HIT-type containing 3 | 0.630 |
TBC1D3G | TADA2A | ENSP00000456861 | ENSP00000481091 | TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.499 |
TBC1D3G | ZNF669 | ENSP00000456861 | ENSP00000342818 | TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.649 |
TBC1D3G | ZNHIT3 | ENSP00000456861 | ENSP00000484687 | TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Zinc finger HIT-type containing 3 | 0.510 |
TBC1D3H | TADA2A | ENSP00000482630 | ENSP00000481091 | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.537 |
TBC1D3H | ZNF669 | ENSP00000482630 | ENSP00000342818 | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.457 |
TBC1D3H | ZNHIT3 | ENSP00000482630 | ENSP00000484687 | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | Zinc finger HIT-type containing 3 | 0.535 |
TONSL | ZNF669 | ENSP00000386239 | ENSP00000342818 | Tonsoku-like protein; Component of the MMS22L-TONSL complex, a complex that stimulates the recombination-dependent repair of stalled or collapsed replication forks. The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication by promoting homologous recombination-mediated repair of replication fork- associated double-strand breaks. It may act by mediating the assembly of RAD51 filaments on ssDNA. Within the complex, may act as a scaffold; Ankyrin repeat domain containing | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.450 |
TRIM28 | ZNF669 | ENSP00000253024 | ENSP00000342818 | Transcription intermediary factor 1-beta; Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at ’Lys-9’ (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 ’Lys-9 and ’Lys-14’ acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression [...] | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.922 |
TUBD1 | ZNF669 | ENSP00000320797 | ENSP00000342818 | Tubulin delta chain; In the elongating spermatid it is associated with the manchette, a specialized microtubule system present during reshaping of the sperm head; Tubulins | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | 0.406 |
ZNF669 | ENSG00000274933 | ENSP00000342818 | ENSP00000481258 | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | TBC1 domain family member 3I; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.413 |
ZNF669 | RBM19 | ENSP00000342818 | ENSP00000442053 | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Probable RNA-binding protein 19; Plays a role in embryo pre-implantation development; RNA binding motif containing | 0.441 |
ZNF669 | TADA2A | ENSP00000342818 | ENSP00000481091 | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | Transcriptional adapter 2-alpha; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double- stranded DNA. Binds dinucleosomes, probably at the linker region between neighboring nucleosomes. Plays a role in chromatin remodeling. May promote TP53/p53 ’Lys-321’ acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote XRCC6 acetylation thus facilitating cell apoptosis in [...] | 0.443 |
ZNF669 | TBC1D3G | ENSP00000342818 | ENSP00000456861 | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | TBC1 domain family member 3G; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.649 |
ZNF669 | TBC1D3H | ENSP00000342818 | ENSP00000482630 | Zinc finger protein 669; May be involved in transcriptional regulation; Zinc fingers C2H2-type | TBC1 domain family member 3H; Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity) | 0.457 |