| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| PPM1G | PPP1CC | ENSP00000342778 | ENSP00000341779 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | 0.757 |
| PPM1G | SNX12 | ENSP00000342778 | ENSP00000481314 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Sorting nexin-12; May be involved in several stages of intracellular trafficking; Sorting nexins | 0.788 |
| PPM1G | SRXN1 | ENSP00000342778 | ENSP00000371388 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | 0.803 |
| PPM1G | STAT6 | ENSP00000342778 | ENSP00000300134 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | 0.785 |
| PPM1G | STMN2 | ENSP00000342778 | ENSP00000429243 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Stathmin-2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity); Stathmins | 0.818 |
| PPM1G | TLE3 | ENSP00000342778 | ENSP00000452871 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); WD repeat domain containing | 0.831 |
| PPM1G | TP53BP1 | ENSP00000342778 | ENSP00000371475 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.775 |
| PPM1G | TTC9C | ENSP00000342778 | ENSP00000325266 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family | 0.795 |
| PPM1G | UBA2 | ENSP00000342778 | ENSP00000246548 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.759 |
| PPM1G | USP7 | ENSP00000342778 | ENSP00000343535 | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53- dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of [...] | 0.786 |
| PPP1CC | PPM1G | ENSP00000341779 | ENSP00000342778 | Serine/threonine-protein phosphatase PP1-gamma catalytic subunit; Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- asso [...] | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | 0.757 |
| SNX12 | PPM1G | ENSP00000481314 | ENSP00000342778 | Sorting nexin-12; May be involved in several stages of intracellular trafficking; Sorting nexins | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | 0.788 |
| SRXN1 | PPM1G | ENSP00000371388 | ENSP00000342778 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | 0.803 |
| SRXN1 | STAT6 | ENSP00000371388 | ENSP00000300134 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | 0.780 |
| SRXN1 | TLE3 | ENSP00000371388 | ENSP00000452871 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | Transducin-like enhancer protein 3; Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity); WD repeat domain containing | 0.817 |
| SRXN1 | TTC9C | ENSP00000371388 | ENSP00000325266 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | Tetratricopeptide repeat domain containing; Belongs to the TTC9 family | 0.825 |
| SRXN1 | UBA2 | ENSP00000371388 | ENSP00000246548 | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2; Ubiquitin like modifier activating enzymes | 0.825 |
| STAT6 | PPM1G | ENSP00000300134 | ENSP00000342778 | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | 0.785 |
| STAT6 | SRXN1 | ENSP00000300134 | ENSP00000371388 | Signal transducer and activator of transcription 6; Carries out a dual function- signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling; SH2 domain containing | Sulfiredoxin-1; Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4. Does not act on PRDX5 or PRDX6. May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase; Belongs to the sulfiredoxin family | 0.780 |
| STMN2 | PPM1G | ENSP00000429243 | ENSP00000342778 | Stathmin-2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity); Stathmins | Protein phosphatase, Mg2+/Mn2+ dependent 1G; Belongs to the PP2C family | 0.818 |
