• Version:
  • 11.0 [archived version]
STRINGSTRING
KRT19 KRT19 KRT35 KRT35 KRT38 KRT38 KRT1 KRT1 KRT36 KRT36 KRT2 KRT2 KRT77 KRT77 KRT28 KRT28 KRT32 KRT32 KRT15 KRT15 KRT10 KRT10
"KRT77" - Keratin, type II cytoskeletal 1b in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
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Textmining
[Homology]
Score
KRT77Keratin, type II cytoskeletal 1b; Keratins, type II; Belongs to the intermediate filament family (578 aa)    
Predicted Functional Partners:
KRT10
Keratin, type I cytoskeletal 10; Keratins, type I (584 aa)
     
0.996
KRT1
Keratin, type II cytoskeletal 1; May regulate the activity of kinases such as PKC and SRC via binding to integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP is a high affinity receptor for kininogen-1/HMWK; Keratins, type II (644 aa)
     
0.995
KRT2
Keratin, type II cytoskeletal 2 epidermal; Probably contributes to terminal cornification. Associated with keratinocyte activation, proliferation and keratinization; Keratins, type II (639 aa)
     
0.994
KRT32
Keratin, type I cuticular Ha2; Keratins, type I; Belongs to the intermediate filament family (448 aa)
     
0.933
KRT35
Keratin, type I cuticular Ha5; Keratins, type I (455 aa)
     
0.932
KRT38
Keratin, type I cuticular Ha8; Keratins, type I; Belongs to the intermediate filament family (456 aa)
     
0.931
KRT28
Keratin, type I cytoskeletal 28; Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs) (464 aa)
     
0.931
KRT15
Keratin, type I cytoskeletal 15; Keratins, type I (456 aa)
     
0.930
KRT19
Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle; Keratins, type I (400 aa)
     
0.930
KRT36
Keratin, type I cuticular Ha6; Keratins, type I (467 aa)
     
0.929
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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