node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARL13B | CFAP36 | ENSP00000377769 | ENSP00000342699 | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development- required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interne [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.822 |
ARL3 | CFAP36 | ENSP00000260746 | ENSP00000342699 | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.947 |
CASC1 | CCDC18 | ENSP00000379310 | ENSP00000383808 | Protein phosphatase 1 regulatory subunits | Coiled-coil domain containing 18 | 0.669 |
CASC1 | CFAP36 | ENSP00000379310 | ENSP00000342699 | Protein phosphatase 1 regulatory subunits | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.648 |
CCDC18 | CASC1 | ENSP00000383808 | ENSP00000379310 | Coiled-coil domain containing 18 | Protein phosphatase 1 regulatory subunits | 0.669 |
CCDC18 | CFAP36 | ENSP00000383808 | ENSP00000342699 | Coiled-coil domain containing 18 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.712 |
CCDC63 | CFAP36 | ENSP00000312399 | ENSP00000342699 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | 0.740 |
CCDC63 | RIBC2 | ENSP00000312399 | ENSP00000483356 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads | RIB43A domain with coiled-coils 2 | 0.725 |
CCDC63 | ROPN1L | ENSP00000312399 | ENSP00000421405 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation | 0.728 |
CCDC63 | TTC29 | ENSP00000312399 | ENSP00000423505 | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads | Tetratricopeptide repeat domain containing | 0.700 |
CFAP36 | ARL13B | ENSP00000342699 | ENSP00000377769 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development- required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interne [...] | 0.822 |
CFAP36 | ARL3 | ENSP00000342699 | ENSP00000260746 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] | 0.947 |
CFAP36 | CASC1 | ENSP00000342699 | ENSP00000379310 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | Protein phosphatase 1 regulatory subunits | 0.648 |
CFAP36 | CCDC18 | ENSP00000342699 | ENSP00000383808 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | Coiled-coil domain containing 18 | 0.712 |
CFAP36 | CCDC63 | ENSP00000342699 | ENSP00000312399 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads | 0.740 |
CFAP36 | IQCK | ENSP00000342699 | ENSP00000324901 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | IQ motif containing K | 0.652 |
CFAP36 | RIBC2 | ENSP00000342699 | ENSP00000483356 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | RIB43A domain with coiled-coils 2 | 0.712 |
CFAP36 | ROPN1L | ENSP00000342699 | ENSP00000421405 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation | 0.674 |
CFAP36 | TSEN2 | ENSP00000342699 | ENSP00000284995 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’- and 3’-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’-cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] | 0.703 |
CFAP36 | TTC29 | ENSP00000342699 | ENSP00000423505 | Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family | Tetratricopeptide repeat domain containing | 0.746 |