• Version:
  • 11.0 [archived version]
STRINGSTRING
CCDC18 CCDC18 CASC1 CASC1 RIBC2 RIBC2 ARL13B ARL13B TTC29 TTC29 CFAP36 CFAP36 ROPN1L ROPN1L CCDC63 CCDC63 IQCK IQCK TSEN2 TSEN2 ARL3 ARL3
"CFAP36" - Cilia- and flagella-associated protein 36 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
CFAP36Cilia- and flagella-associated protein 36; May act as an effector for ARL3; Belongs to the CFAP36 family (367 aa)    
Predicted Functional Partners:
ARL3
ADP-ribosylation factor-like protein 3; Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase- activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapt [...] (182 aa)
     
 
  0.947
ARL13B
ADP-ribosylation factor-like protein 13B; Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development- required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling. Regulates the migration and placement of postmitotic interne [...] (428 aa)
     
 
  0.822
TTC29
Tetratricopeptide repeat domain containing (501 aa)
           
  0.746
CCDC63
Coiled-coil domain-containing protein 63; Plays a role in spermiogenesis. Involved in the elongation of flagella and the formation of sperm heads (563 aa)
           
  0.740
RIBC2
RIB43A domain with coiled-coils 2 (382 aa)
           
  0.712
CCDC18
Coiled-coil domain containing 18 (1299 aa)
           
  0.712
TSEN2
tRNA-splicing endonuclease subunit Sen2; Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5’- and 3’-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2’,3’-cyclic phosphate and 5’-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural [...] (465 aa)
           
  0.703
ROPN1L
Ropporin-1-like protein; Important for male fertility. With ROPN1, involved in fibrous sheath integrity and sperm motility, plays a role in PKA- dependent signaling processes required for spermatozoa capacitation (230 aa)
           
  0.674
IQCK
IQ motif containing K (287 aa)
           
  0.652
CASC1
Protein phosphatase 1 regulatory subunits (722 aa)
     
   
  0.648
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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