| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CXorf67 | HOXC8 | ENSP00000342680 | ENSP00000040584 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family | 0.612 |
| CXorf67 | JAZF1 | ENSP00000342680 | ENSP00000283928 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | 0.620 |
| CXorf67 | MBTD1 | ENSP00000342680 | ENSP00000468304 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | 0.736 |
| CXorf67 | MEAF6 | ENSP00000342680 | ENSP00000362166 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | 0.706 |
| CXorf67 | NUTM2A | ENSP00000342680 | ENSP00000371126 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | NUT family member 2A | 0.700 |
| CXorf67 | PCDH19 | ENSP00000342680 | ENSP00000362125 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Protocadherin-19; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | 0.654 |
| CXorf67 | TP53BP1 | ENSP00000342680 | ENSP00000371475 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | TP53-binding protein 1; Double-strand break (DSB) repair protein involved in response to DNA damage, telomere dynamics and class-switch recombination (CSR) during antibody genesis. Plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs and specifically counteracting the function of the homologous recombination (HR) repair protein BRCA1. In response to DSBs, phosphorylation by ATM promotes interaction with RIF1 and dissociation from NUDT16L1/TIRR, leading to recruitment to DSBs si [...] | 0.673 |
| CXorf67 | ZC3H7A | ENSP00000342680 | ENSP00000379773 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.672 |
| CXorf67 | ZC3H7B | ENSP00000342680 | ENSP00000345793 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Zinc finger CCCH domain-containing protein 7B; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the ’ATA(A/T)’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.678 |
| CXorf67 | ZFHX4 | ENSP00000342680 | ENSP00000430497 | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.682 |
| HOXC8 | CXorf67 | ENSP00000040584 | ENSP00000342680 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | 0.612 |
| HOXC8 | PCDH19 | ENSP00000040584 | ENSP00000362125 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family | Protocadherin-19; Potential calcium-dependent cell-adhesion protein; Non-clustered protocadherins | 0.552 |
| HOXC8 | ZFHX4 | ENSP00000040584 | ENSP00000430497 | Homeobox protein Hox-C8; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis; Belongs to the Antp homeobox family | Zinc finger homeobox protein 4; May play a role in neural and muscle differentiation (By similarity). May be involved in transcriptional regulation; ZF class homeoboxes and pseudogenes | 0.592 |
| JAZF1 | CXorf67 | ENSP00000283928 | ENSP00000342680 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | 0.620 |
| JAZF1 | MBTD1 | ENSP00000283928 | ENSP00000468304 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | 0.520 |
| JAZF1 | MEAF6 | ENSP00000283928 | ENSP00000362166 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | Chromatin modification-related protein MEAF6; Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in viv [...] | 0.918 |
| JAZF1 | NUTM2A | ENSP00000283928 | ENSP00000371126 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | NUT family member 2A | 0.702 |
| JAZF1 | ZC3H7A | ENSP00000283928 | ENSP00000379773 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | Zinc finger CCCH domain-containing protein 7A; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 3’-ATA(A/T)-5’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.445 |
| JAZF1 | ZC3H7B | ENSP00000283928 | ENSP00000345793 | Juxtaposed with another zinc finger protein 1; Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2. Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (By similarity). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (By similarity). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (By similarity). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (By simi [...] | Zinc finger CCCH domain-containing protein 7B; May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the ’ATA(A/T)’ motif in the apical loop; Tetratricopeptide repeat domain containing | 0.538 |
| MBTD1 | CXorf67 | ENSP00000468304 | ENSP00000342680 | MBT domain-containing protein 1; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). Specifically binds to monomethylated and dimethylated ’Lys-20’ on histone H4; MBT domain containing | Uncharacterized protein CXorf67; Chromosome X open reading frame 67 | 0.736 |
