| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANAPC7 | CEP95 | ENSP00000394394 | ENSP00000450461 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Centrosomal protein 95 | 0.531 |
| ANAPC7 | FAM184A | ENSP00000394394 | ENSP00000342604 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Protein FAM184A; Family with sequence similarity 184 member A | 0.526 |
| ANAPC7 | LRRC8D | ENSP00000394394 | ENSP00000338887 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.425 |
| C9orf131 | FAM184A | ENSP00000308279 | ENSP00000342604 | Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131 | Protein FAM184A; Family with sequence similarity 184 member A | 0.494 |
| CAMTA2 | FAM184A | ENSP00000412886 | ENSP00000342604 | Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor; Belongs to the CAMTA family | Protein FAM184A; Family with sequence similarity 184 member A | 0.557 |
| CEP250 | FAM184A | ENSP00000380661 | ENSP00000342604 | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | Protein FAM184A; Family with sequence similarity 184 member A | 0.512 |
| CEP95 | ANAPC7 | ENSP00000450461 | ENSP00000394394 | Centrosomal protein 95 | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | 0.531 |
| CEP95 | FAM184A | ENSP00000450461 | ENSP00000342604 | Centrosomal protein 95 | Protein FAM184A; Family with sequence similarity 184 member A | 0.566 |
| CEP95 | LRRC8D | ENSP00000450461 | ENSP00000338887 | Centrosomal protein 95 | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.468 |
| CEP95 | PAQR8 | ENSP00000450461 | ENSP00000406197 | Centrosomal protein 95 | Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family | 0.419 |
| FAM184A | ANAPC7 | ENSP00000342604 | ENSP00000394394 | Protein FAM184A; Family with sequence similarity 184 member A | Anaphase-promoting complex subunit 7; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains; Belongs to the APC7 family | 0.526 |
| FAM184A | C9orf131 | ENSP00000342604 | ENSP00000308279 | Protein FAM184A; Family with sequence similarity 184 member A | Uncharacterized protein C9orf131; Chromosome 9 open reading frame 131 | 0.494 |
| FAM184A | CAMTA2 | ENSP00000342604 | ENSP00000412886 | Protein FAM184A; Family with sequence similarity 184 member A | Calmodulin-binding transcription activator 2; Transcription activator. May act as tumor suppressor; Belongs to the CAMTA family | 0.557 |
| FAM184A | CEP250 | ENSP00000342604 | ENSP00000380661 | Protein FAM184A; Family with sequence similarity 184 member A | Centrosome-associated protein CEP250; Probably plays an important role in centrosome cohesion during interphase | 0.512 |
| FAM184A | CEP95 | ENSP00000342604 | ENSP00000450461 | Protein FAM184A; Family with sequence similarity 184 member A | Centrosomal protein 95 | 0.566 |
| FAM184A | FOXRED1 | ENSP00000342604 | ENSP00000263578 | Protein FAM184A; Family with sequence similarity 184 member A | FAD-dependent oxidoreductase domain-containing protein 1; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly | 0.430 |
| FAM184A | JKAMP | ENSP00000342604 | ENSP00000450749 | Protein FAM184A; Family with sequence similarity 184 member A | JNK1/MAPK8-associated membrane protein; May be a regulator of the duration of MAPK8 activity in response to various stress stimuli. Facilitates degradation of misfolded endoplasmic reticulum (ER) luminal proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (By similarity) | 0.440 |
| FAM184A | LRRC8D | ENSP00000342604 | ENSP00000338887 | Protein FAM184A; Family with sequence similarity 184 member A | Volume-regulated anion channel subunit LRRC8D; Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. LRRC8A and LRRC8D are required for the uptak [...] | 0.497 |
| FAM184A | PAQR8 | ENSP00000342604 | ENSP00000406197 | Protein FAM184A; Family with sequence similarity 184 member A | Membrane progestin receptor beta; Plasma membrane progesterone (P4) receptor coupled to G proteins. Seems to act through a G(i) mediated pathway. May be involved in oocyte maturation (By similarity). Also binds dehydroepiandrosterone (DHEA), pregnanolone, pregnenolone and allopregnanolone; Belongs to the ADIPOR family | 0.446 |
| FAM184A | PROM2 | ENSP00000342604 | ENSP00000318270 | Protein FAM184A; Family with sequence similarity 184 member A | Prominin-2; Prominin 2 | 0.620 |
