node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C15orf61 | CHRD | ENSP00000342254 | ENSP00000204604 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity) | 0.405 |
C15orf61 | IQCH | ENSP00000342254 | ENSP00000336861 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | IQ domain-containing protein H; May play a regulatory role in spermatogenesis | 0.441 |
C15orf61 | MAP2K5 | ENSP00000342254 | ENSP00000178640 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily | 0.418 |
C15orf61 | SDCCAG3 | ENSP00000342254 | ENSP00000349929 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | Serologically defined colon cancer antigen 3; May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 | 0.442 |
C15orf61 | SKOR1 | ENSP00000342254 | ENSP00000343200 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling; SKI transcriptional corepressors | 0.582 |
C15orf61 | T | ENSP00000342254 | ENSP00000296946 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | Brachyury protein; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site | 0.452 |
C15orf61 | WDR83OS | ENSP00000342254 | ENSP00000468969 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | Protein Asterix; WD repeat domain 83 opposite strand | 0.405 |
CHRD | C15orf61 | ENSP00000204604 | ENSP00000342254 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity) | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.405 |
CHRD | T | ENSP00000204604 | ENSP00000296946 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity) | Brachyury protein; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site | 0.633 |
CHRD | WDR83OS | ENSP00000204604 | ENSP00000468969 | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity) | Protein Asterix; WD repeat domain 83 opposite strand | 0.511 |
IQCH | C15orf61 | ENSP00000336861 | ENSP00000342254 | IQ domain-containing protein H; May play a regulatory role in spermatogenesis | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.441 |
MAP2K5 | C15orf61 | ENSP00000178640 | ENSP00000342254 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.418 |
MAP2K5 | SKOR1 | ENSP00000178640 | ENSP00000343200 | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling; SKI transcriptional corepressors | 0.784 |
SDCCAG3 | C15orf61 | ENSP00000349929 | ENSP00000342254 | Serologically defined colon cancer antigen 3; May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1. Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.442 |
SKOR1 | C15orf61 | ENSP00000343200 | ENSP00000342254 | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling; SKI transcriptional corepressors | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.582 |
SKOR1 | MAP2K5 | ENSP00000343200 | ENSP00000178640 | SKI family transcriptional corepressor 1; Acts as a transcriptional corepressor of LBX1 (By similarity). Inhibits BMP signaling; SKI transcriptional corepressors | Dual specificity mitogen-activated protein kinase kinase 5; Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily | 0.784 |
T | C15orf61 | ENSP00000296946 | ENSP00000342254 | Brachyury protein; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.452 |
T | CHRD | ENSP00000296946 | ENSP00000204604 | Brachyury protein; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site | Chordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity) | 0.633 |
T | WDR83OS | ENSP00000296946 | ENSP00000468969 | Brachyury protein; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site | Protein Asterix; WD repeat domain 83 opposite strand | 0.406 |
WDR83OS | C15orf61 | ENSP00000468969 | ENSP00000342254 | Protein Asterix; WD repeat domain 83 opposite strand | Uncharacterized protein C15orf61; Chromosome 15 open reading frame 61 | 0.405 |