HHIPL2 protein (human) - STRING database

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HHIPL2

HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family (724 aa)

Predicted Functional Partners:

SGSM3

0.658

QSOX1

0.542

SRPR

0.537

GPRC5B

0.515

RGMB

0.497

HIP1

0.477

PLEKHH1

0.471

NTN5

0.441

BDKRB1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BDKRB1	HHIPL2	ENSP00000216629	ENSP00000342118	B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.405
GPRC5B	HHIPL2	ENSP00000300571	ENSP00000342118	G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.515
HHIPL2	BDKRB1	ENSP00000342118	ENSP00000216629	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	B1 bradykinin receptor; This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation	0.405
HHIPL2	GPRC5B	ENSP00000342118	ENSP00000300571	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	G-protein coupled receptor family C group 5 member B; Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways; G protein-coupled receptors, Class C orphans	0.515
HHIPL2	HIP1	ENSP00000342118	ENSP00000336747	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	Huntingtin-interacting protein 1; Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases [...]	0.477
HHIPL2	NTN5	ENSP00000342118	ENSP00000270235	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	Netrin-5; Netrin 5; Netrins	0.441
HHIPL2	PLEKHH1	ENSP00000342118	ENSP00000330278	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	Pleckstrin homology, MyTH4 and FERM domain containing H1	0.471
HHIPL2	QSOX1	ENSP00000342118	ENSP00000356574	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation; Belongs to the quiescin-sulfhydryl oxidase (QSOX) family	0.542
HHIPL2	RGMB	ENSP00000342118	ENSP00000308219	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth	0.497
HHIPL2	SGSM3	ENSP00000342118	ENSP00000248929	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells; Small G protein signaling modulators	0.658
HHIPL2	SRPR	ENSP00000342118	ENSP00000328023	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	Signal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system	0.537
HIP1	HHIPL2	ENSP00000336747	ENSP00000342118	Huntingtin-interacting protein 1; Plays a role in clathrin-mediated endocytosis and trafficking. Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription. May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases [...]	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.477
NTN5	HHIPL2	ENSP00000270235	ENSP00000342118	Netrin-5; Netrin 5; Netrins	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.441
PLEKHH1	HHIPL2	ENSP00000330278	ENSP00000342118	Pleckstrin homology, MyTH4 and FERM domain containing H1	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.471
QSOX1	HHIPL2	ENSP00000356574	ENSP00000342118	Sulfhydryl oxidase 1; Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor- suppressing capabilities being involved in growth regulation; Belongs to the quiescin-sulfhydryl oxidase (QSOX) family	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.542
RGMB	HHIPL2	ENSP00000308219	ENSP00000342118	RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.497
RGMB	SGSM3	ENSP00000308219	ENSP00000248929	RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth	Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells; Small G protein signaling modulators	0.448
SGSM3	HHIPL2	ENSP00000248929	ENSP00000342118	Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells; Small G protein signaling modulators	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.658
SGSM3	RGMB	ENSP00000248929	ENSP00000308219	Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells; Small G protein signaling modulators	RGM domain family member B; Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth	0.448
SRPR	HHIPL2	ENSP00000328023	ENSP00000342118	Signal recognition particle receptor subunit alpha; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system	HHIP-like protein 2; HHIP like 2; Belongs to the HHIP family	0.537

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