SIMC1 protein (human) - STRING database

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SIMC1

SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1 (457 aa)

Predicted Functional Partners:

SPHKAP

0.717

LRRN2

0.717

SOBP

0.644

OR2T34

0.543

TUFT1

0.535

B4GALT7

0.493

RNF111

0.451

TSTA3

0.451

THG1L

0.447

ZNF354B

0.442

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B4GALT7	SIMC1	ENSP00000029410	ENSP00000342075	Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	0.493
LRRN2	OR2T34	ENSP00000356143	ENSP00000330904	Leucine rich repeat neuronal 2; I-set domain containing	Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2	0.475
LRRN2	SIMC1	ENSP00000356143	ENSP00000342075	Leucine rich repeat neuronal 2; I-set domain containing	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	0.717
LRRN2	SPHKAP	ENSP00000356143	ENSP00000375909	Leucine rich repeat neuronal 2; I-set domain containing	A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1; A-kinase anchoring proteins	0.733
OR2T34	LRRN2	ENSP00000330904	ENSP00000356143	Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2	Leucine rich repeat neuronal 2; I-set domain containing	0.475
OR2T34	SIMC1	ENSP00000330904	ENSP00000342075	Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	0.543
OR2T34	SPHKAP	ENSP00000330904	ENSP00000375909	Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2	A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1; A-kinase anchoring proteins	0.489
RNF111	SIMC1	ENSP00000453872	ENSP00000342075	E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and [...]	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	0.451
SIMC1	B4GALT7	ENSP00000342075	ENSP00000029410	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Beta-1,4-galactosyltransferase 7; Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts; Belongs to the glycosyltransferase 7 family	0.493
SIMC1	LRRN2	ENSP00000342075	ENSP00000356143	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Leucine rich repeat neuronal 2; I-set domain containing	0.717
SIMC1	OR2T34	ENSP00000342075	ENSP00000330904	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Olfactory receptor 2T34; Odorant receptor; Olfactory receptors, family 2	0.543
SIMC1	RNF111	ENSP00000342075	ENSP00000453872	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	E3 ubiquitin-protein ligase Arkadia; E3 ubiquitin-protein ligase. Required for mesoderm patterning during embryonic development (By similarity). Acts as an enhancer of the transcriptional responses of the SMAD2/SMAD3 effectors, which are activated downstream of BMP. Acts by mediating ubiquitination and degradation of SMAD inhibitors such as SMAD7, inducing their proteasomal degradation and thereby enhancing the transcriptional activity of TGF-beta and BMP. In addition to enhance transcription of SMAD2/SMAD3 effectors, also regulates their turnover by mediating their ubiquitination and [...]	0.451
SIMC1	SOBP	ENSP00000342075	ENSP00000318900	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Sine oculis-binding protein homolog; Implicated in development of the cochlea	0.644
SIMC1	SPHKAP	ENSP00000342075	ENSP00000375909	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1; A-kinase anchoring proteins	0.717
SIMC1	THG1L	ENSP00000342075	ENSP00000231198	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Probable tRNA(His) guanylyltransferase; Adds a GMP to the 5’-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis	0.447
SIMC1	TSTA3	ENSP00000342075	ENSP00000398803	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	GDP-L-fucose synthase; Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction; Short chain dehydrogenase/reductase superfamily	0.451
SIMC1	TUFT1	ENSP00000342075	ENSP00000357842	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Tuftelin; Involved in the mineralization and structural organization of enamel; Belongs to the tuftelin family	0.535
SIMC1	ZNF354B	ENSP00000342075	ENSP00000327143	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	Zinc finger protein 354B; May be involved in transcriptional regulation; Zinc fingers C2H2-type	0.442
SOBP	SIMC1	ENSP00000318900	ENSP00000342075	Sine oculis-binding protein homolog; Implicated in development of the cochlea	SUMO-interacting motif-containing protein 1; SUMO interacting motifs containing 1	0.644
SPHKAP	LRRN2	ENSP00000375909	ENSP00000356143	A-kinase anchor protein SPHKAP; Anchoring protein that binds preferentially to the type I regulatory subunit of c-AMP-dependent protein kinase (PKA type I) and targets it to distinct subcellular compartments. May act as a converging factor linking cAMP and sphingosine signaling pathways. Plays a regulatory role in the modulation of SPHK1; A-kinase anchoring proteins	Leucine rich repeat neuronal 2; I-set domain containing	0.733

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