| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ANKRD12 | PTCHD4 | ENSP00000262126 | ENSP00000341914 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | 0.418 |
| ANKRD12 | PTX4 | ENSP00000262126 | ENSP00000293922 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Pentraxin-4; Long pentraxins | 0.441 |
| ANKRD12 | SAMD10 | ENSP00000262126 | ENSP00000358902 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Sterile alpha motif domain containing 10 | 0.499 |
| ANKRD12 | SPATA5L1 | ENSP00000262126 | ENSP00000305494 | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | Spermatogenesis-associated protein 5-like protein 1; Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. AFG2 subfamily | 0.502 |
| C18orf8 | PTCHD2 | ENSP00000269221 | ENSP00000294484 | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells (By similarity) | 0.557 |
| C18orf8 | PTCHD4 | ENSP00000269221 | ENSP00000341914 | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | 0.481 |
| DLGAP2 | PTCHD4 | ENSP00000400258 | ENSP00000341914 | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane; Belongs to the SAPAP family | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | 0.631 |
| ENC1 | PTCHD4 | ENSP00000479101 | ENSP00000341914 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | 0.425 |
| ENC1 | SNX33 | ENSP00000479101 | ENSP00000311427 | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | Sorting nexin-33; Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macr [...] | 0.799 |
| NHSL2 | PTCHD4 | ENSP00000424079 | ENSP00000341914 | NHS-like protein 2; NHS like 2 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | 0.511 |
| NHSL2 | PTX4 | ENSP00000424079 | ENSP00000293922 | NHS-like protein 2; NHS like 2 | Pentraxin-4; Long pentraxins | 0.458 |
| NHSL2 | SAMD10 | ENSP00000424079 | ENSP00000358902 | NHS-like protein 2; NHS like 2 | Sterile alpha motif domain containing 10 | 0.540 |
| NHSL2 | SPATA5L1 | ENSP00000424079 | ENSP00000305494 | NHS-like protein 2; NHS like 2 | Spermatogenesis-associated protein 5-like protein 1; Spermatogenesis associated 5 like 1; Belongs to the AAA ATPase family. AFG2 subfamily | 0.473 |
| PTCHD2 | C18orf8 | ENSP00000294484 | ENSP00000269221 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells (By similarity) | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | 0.557 |
| PTCHD2 | PTCHD4 | ENSP00000294484 | ENSP00000341914 | Protein dispatched homolog 3; Plays a role in neuronal proliferation and differentiation. Plays a role in the accumulation of cellular cholesterol (By similarity). Involved in intracellular lipid droplet formation. May contribute to cholesterol homeostasis in neuronal cells (By similarity) | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | 0.744 |
| PTCHD4 | ANKRD12 | ENSP00000341914 | ENSP00000262126 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | Ankyrin repeat domain-containing protein 12; May recruit HDACs to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation; Ankyrin repeat domain containing | 0.418 |
| PTCHD4 | C18orf8 | ENSP00000341914 | ENSP00000269221 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | Uncharacterized protein C18orf8; Chromosome 18 open reading frame 8; Belongs to the Mic1 family | 0.481 |
| PTCHD4 | DLGAP2 | ENSP00000341914 | ENSP00000400258 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | Disks large-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane; Belongs to the SAPAP family | 0.631 |
| PTCHD4 | ENC1 | ENSP00000341914 | ENSP00000479101 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | Ectoderm-neural cortex protein 1; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism; BTB domain containing | 0.425 |
| PTCHD4 | NHSL2 | ENSP00000341914 | ENSP00000424079 | Patched domain-containing protein 4; Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down- regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells; Belongs to the patched family | NHS-like protein 2; NHS like 2 | 0.511 |
