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  • 11.0 [archived version]
STRINGSTRING
A3GALT2 A3GALT2 CLGN CLGN TES TES C17orf67 C17orf67 SYT3 SYT3 BSPH1 BSPH1 DHX34 DHX34 RUFY1 RUFY1 CATSPER1 CATSPER1 PHLDB3 PHLDB3 C19orf68 C19orf68
"BSPH1" - Binder of sperm protein homolog 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
BSPH1Binder of sperm protein homolog 1; Binds sperm in vitro and promotes sperm capacitation. Specifically promotes capacitation induced by high density lipoproteins (HDLs). Also binds heparin, phospholipid liposomes, and weakly to gelatin. Does not bind chondroitin sulfate B (132 aa)    
Predicted Functional Partners:
C17orf67
Uncharacterized protein C17orf67; Chromosome 17 open reading frame 67 (90 aa)
           
  0.685
DHX34
Probable ATP-dependent RNA helicase DHX34; Probable ATP-binding RNA helicase; DEAH-box helicases (1143 aa)
           
  0.669
SYT3
Synaptotagmin-3; Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes; Synaptotagmins (590 aa)
           
  0.638
TES
Testin; Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor. Inhibits tumor cell growth; LIM domain containing (421 aa)
           
  0.634
C19orf68
Uncharacterized protein ZSWIM9; Chromosome 19 open reading frame 68 (920 aa)
           
  0.544
CLGN
Calmegin; Functions during spermatogenesis as a chaperone for a range of client proteins that are important for sperm adhesion onto the egg zona pellucida and for subsequent penetration of the zona pellucida. Required for normal sperm migration from the uterus into the oviduct. Required for normal male fertility. Binds calcium ions (By similarity) (610 aa)
           
  0.529
A3GALT2
Alpha-1,3-galactosyltransferase 2; Synthesizes the galactose-alpha(1,3)-galactose group on the glycosphingolipid isoglobotrihexosylceramide or isogloboside 3 (iGb3) by catalyzing the transfer of galactose from UDP-Galactose to its acceptor molecule Gal-beta-1,4-Glc-ceramide. Can also catalyze the addition of galactose to iGb3 itself to form polygalactose structures; Belongs to the glycosyltransferase 6 family (340 aa)
           
  0.515
CATSPER1
Cation channel sperm-associated protein 1; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte; Cation channels sperm associated (780 aa)
           
  0.513
PHLDB3
Pleckstrin homology like domain family B member 3 (640 aa)
           
  0.512
RUFY1
RUN and FYVE domain-containing protein 1; Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking; Zinc fingers FYVE-type (708 aa)
           
  0.507
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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