node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EMG1 | THYN1 | ENSP00000470560 | ENSP00000341657 | Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-riboso [...] | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC | 0.604 |
EMG1 | TMEM201 | ENSP00000470560 | ENSP00000344503 | Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-riboso [...] | Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery | 0.638 |
HMCES | LYAR | ENSP00000372955 | ENSP00000345917 | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | 0.578 |
HMCES | OGFOD1 | ENSP00000372955 | ENSP00000457258 | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | 0.543 |
HMCES | SMEK2 | ENSP00000372955 | ENSP00000483228 | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | 0.502 |
HMCES | THYN1 | ENSP00000372955 | ENSP00000341657 | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC | 0.599 |
HMCES | TMA16 | ENSP00000372955 | ENSP00000351380 | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | Translation machinery associated 16 homolog | 0.723 |
LYAR | HMCES | ENSP00000345917 | ENSP00000372955 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | 0.578 |
LYAR | OGFOD1 | ENSP00000345917 | ENSP00000457258 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | 0.567 |
LYAR | SMEK2 | ENSP00000345917 | ENSP00000483228 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | 0.523 |
LYAR | THYN1 | ENSP00000345917 | ENSP00000341657 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC | 0.611 |
LYAR | TMA16 | ENSP00000345917 | ENSP00000351380 | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | Translation machinery associated 16 homolog | 0.764 |
OGFOD1 | HMCES | ENSP00000457258 | ENSP00000372955 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | 0.543 |
OGFOD1 | LYAR | ENSP00000457258 | ENSP00000345917 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | 0.567 |
OGFOD1 | SMEK2 | ENSP00000457258 | ENSP00000483228 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | 0.515 |
OGFOD1 | THYN1 | ENSP00000457258 | ENSP00000341657 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC | 0.571 |
OGFOD1 | TMA16 | ENSP00000457258 | ENSP00000351380 | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | Translation machinery associated 16 homolog | 0.708 |
SMEK2 | HMCES | ENSP00000483228 | ENSP00000372955 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction | 0.502 |
SMEK2 | LYAR | ENSP00000483228 | ENSP00000345917 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type | 0.523 |
SMEK2 | OGFOD1 | ENSP00000483228 | ENSP00000457258 | Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family | 0.515 |