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  • 11.0 [archived version]
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TMEM201 TMEM201 EMG1 EMG1 SPPL2B SPPL2B TRPT1 TRPT1 THYN1 THYN1 WDR76 WDR76 SMEK2 SMEK2 OGFOD1 OGFOD1 HMCES HMCES TMA16 TMA16 LYAR LYAR
"THYN1" - Thymocyte nuclear protein 1 in Homo sapiens
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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THYN1Thymocyte nuclear protein 1; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC (225 aa)    
Predicted Functional Partners:
TMA16
Translation machinery associated 16 homolog (203 aa)
     
   
  0.751
WDR76
WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC; WD repeat domain containing (626 aa)
           
  0.749
TRPT1
tRNA 2’-phosphotransferase 1; Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2’-phosphate from ligated tRNA to NAD to produce ADP-ribose 1’’-2’’ cyclic phosphate; Belongs to the KptA/TPT1 family (255 aa)
     
   
  0.740
SPPL2B
Signal peptide peptidase-like 2B; Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF-alpha (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. May play a role in the regulation of innate and adaptive immunity. Catalyzes the intramembrane cleavage of the simian foamy virus processed leader peptide gp18 of the envelope glycoprotein gp130 dependen [...] (592 aa)
           
  0.659
LYAR
Cell growth-regulating nucleolar protein; Zinc fingers C2HC-type (379 aa)
     
   
  0.611
TMEM201
Transmembrane protein 201; Involved in nuclear movement during fibroblast polarization and migration. Proposed to be involved in actin- dependent nuclear movement via association with transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow (By similarity). Overexpression can recruit Ran GTPase to the nuclear periphery (666 aa)
           
  0.611
EMG1
Ribosomal RNA small subunit methyltransferase NEP1; S-adenosyl-L-methionine-dependent pseudouridine N(1)- methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position. Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-riboso [...] (244 aa)
     
   
  0.604
HMCES
Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Specifically binds 5-hydroxymethylcytosine (5hmC)- containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (By similarity). May act as a peptidase; experimental evidences are however required to confirm this prediction (354 aa)
     
   
  0.599
SMEK2
Serine/threonine-protein phosphatase 4 regulatory subunit 3B; Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers (849 aa)
 
       
  0.573
OGFOD1
Prolyl 3-hydroxylase OGFOD1; Prolyl 3-hydroxylase that catalyzes 3-hydroxylation of ’Pro-62’ of small ribosomal subunit uS12 (RPS23), thereby regulating protein translation termination efficiency. Involved in stress granule formation; Belongs to the TPA1 family (542 aa)
         
  0.571
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo sapiens, human, man
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